INT205618

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 23
Disease Relevance 9.26
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Renbp)
Anatomy Link Frequency
extracellular matrix 2
liver 1
hip 1
corpus callosum 1
connective tissue 1
Renbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 68 100.00 Very High Very High Very High
alcohol 6 100.00 Very High Very High Very High
cytokine 4 99.56 Very High Very High Very High
Action potential 6 98.70 Very High Very High Very High
Inflammation 23 97.92 Very High Very High Very High
Arthritis 15 88.08 High High
primary somatosensory cortex 16 80.40 Quite High
Thalamus 2 76.56 Quite High
Bile 9 69.60 Quite High
Hippocampus 4 59.72 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 10 100.00 Very High Very High Very High
Endometriosis (extended) 4 100.00 Very High Very High Very High
Hip Fractures 31 99.84 Very High Very High Very High
Neointima 24 99.40 Very High Very High Very High
Hyperplasia 31 99.00 Very High Very High Very High
Obesity 21 98.52 Very High Very High Very High
Vasculitis 26 98.28 Very High Very High Very High
Restenosis 98 98.22 Very High Very High Very High
Growth Problems 55 97.12 Very High Very High Very High
Aging 240 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From this dataset a comparison group was drawn, individually matched on age and gender (6 persons in the general population for each person in the short stature sample).
Gene_expression (matched) of age associated with growth problems
1) Confidence 0.26 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1838413 Disease Relevance 0.97 Pain Relevance 0.26
Thus, our data demonstrate reduced PPS due to an overall reduction of the first response as a form of modified PPS developing at old age.



Gene_expression (developing) of age
2) Confidence 0.20 Published 2010 Journal Cerebral Cortex (New York, NY) Section Abstract Doc Link PMC2852507 Disease Relevance 0.07 Pain Relevance 0
Evoked action potentials revealed comparable shapes and amplitudes in all animals of all age groups, and there were no differences in RF size and in threshold between old and adult animals (Reinke and Dinse 1996).
Gene_expression (groups) of age associated with action potential
3) Confidence 0.20 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2852507 Disease Relevance 0.09 Pain Relevance 0.13
In the Netherlands, data from the Dutch Medical Registry shows that between 1972–1987 the age-adjusted incidence of hip fractures rose linearly from 479/100 000 to 669/100 000 per year in women and from 198/100 000 to 308/100 000 per year in men aged ?
Gene_expression (incidence) of age-adjusted in hip associated with hip fractures
4) Confidence 0.17 Published 2011 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC3004072 Disease Relevance 0.29 Pain Relevance 0
The relatively tight clustering observed among animals (biological replicates) of the same sex and age group illustrates the degree of reproducibility in sex- and age-related expression profiles.
Gene_expression (expression) of age
5) Confidence 0.14 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
Data for each spot across all arrays were mean-scaled to calculate relative fold-change differences in expression for each sex and age.
Gene_expression (expression) of age
6) Confidence 0.14 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.05 Pain Relevance 0.03
This in vivo study shows that expression of AGE receptors and neointima hyperplasia are significantly suppressed in balloon-injured rats treated with alagebrium.


Gene_expression (expression) of AGE associated with neointima and hyperplasia
7) Confidence 0.13 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2978295 Disease Relevance 0.76 Pain Relevance 0.03
AGE-mediated cross-link formation in proteins such as collagen may result not only in stiffening of the arteries, but also in increased extracellular matrix formation and increased vascular inflammation, which results in increased risk of neointimal proliferation.7)19-21) AGE accumulation and formation of cross links are associated with increased proinflammatory cytokine levels and increased expression of AGE receptors (RAGEs), resulting in increased vascular inflammation.16)21)22)
Gene_expression (expression) of AGE in extracellular matrix associated with inflammation, vasculitis and cytokine
8) Confidence 0.13 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 1.01 Pain Relevance 0.15
The genes for two of these transcription factors, Dbp and Tef, were found to be differentially expressed throughout the life cycle in an age- and sex-specific manner (Figure 5A) and also to be highly correlated between the sexes (Pearson, R = 0.94).
Gene_expression (expressed) of age
9) Confidence 0.12 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.16 Pain Relevance 0
Additionally, 3D-PCA permits the viewing of individual animal data as they contribute to the average or composite expression for one sex and age group.
Gene_expression (expression) of age
10) Confidence 0.12 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
In this case, Phgdh fell into clusters 22 and 29 (male and female, respectively), demonstrating transient up-regulation between 5 and 6 weeks with declining expression in subsequent age groups.
Gene_expression (expression) of age
11) Confidence 0.12 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.14 Pain Relevance 0
The initial filtering criteria of p < 0.05 for sex or age difference with an absolute fold-change greater than or equal to 1.5 in relative expression at any age was used to define a set of 7,951 differentially expressed features comprising 3,770 unique Entrez Gene IDs or differentially expressed genes (DEGs).
Gene_expression (expression) of age
12) Confidence 0.12 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
Igf-2 exhibits high expression at 2 weeks (100- to 500-fold change above average for female and male, respectively) followed by relatively low and constant expression at the remaining age groups.
Gene_expression (expression) of age
13) Confidence 0.12 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.08 Pain Relevance 0
A univariate ANOVA was computed for corpus callosum volume, using Age at Treatment (3 levels; P1, 3, 5) and Treatment (2 levels; Sham, Lesion) as fixed factors (Figure 2).
Gene_expression (using) of Age in corpus callosum
14) Confidence 0.12 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2204005 Disease Relevance 0.06 Pain Relevance 0
The cellular mechanisms of AGE-induced connective tissue and extracellular matrix expression were decreased in the alagebrium-treated group.
Gene_expression (expression) of AGE in extracellular matrix
15) Confidence 0.11 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2978295 Disease Relevance 0.82 Pain Relevance 0.03
The composite liver gene expression profiles for all genes (unfiltered) displayed good reproducibility in general between animals of the same sex and age group with average Pearson's correlations of R = 0.986 between biological replicates of the same sex and age.
Gene_expression (expression) of age in liver
16) Confidence 0.11 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.13 Pain Relevance 0.03
Cyp1a2, a notable xenobiotic and drug metabolizer and known target of Ahr, exhibited roughly parallel expression between sexes with maximum relative expression (~1.5 fold) peaking around 6 to 8 weeks followed by declining expression with age.
Gene_expression (expression) of age
17) Confidence 0.11 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
The ISR rate in the high-AGE (>170 U/ml) group (40.1%) was significantly higher than in the low-AGE group (?
Gene_expression (group) of AGE associated with restenosis
18) Confidence 0.07 Published 2005 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2823061 Disease Relevance 1.15 Pain Relevance 0
As there was no significant statistical correlation between age and MMP 1, 3, and 9 expression, we do not think that would explain our findings.
Gene_expression (expression) of age associated with metalloproteinase
19) Confidence 0.06 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.94 Pain Relevance 0.25
The AGE serum levels in the 203 patients measured in this study ranged from 48.5 U/ml to 283.3 U/ml (151.1 ± 56.5 U/ml, mean ± SD).
Gene_expression (levels) of AGE
20) Confidence 0.06 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2823061 Disease Relevance 0.17 Pain Relevance 0

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