INT205654

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 11.53
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FUS) cell death (FUS) nucleolus (FUS)
RNA binding (FUS) nucleus (FUS) intracellular (FUS)
Anatomy Link Frequency
urine 1
FUS (Homo sapiens)
Pain Link Frequency Relevance Heat
iatrogenic 5 99.32 Very High Very High Very High
Inflammatory response 5 91.08 High High
Onset of action 12 62.76 Quite High
Arthritis 4 45.52 Quite Low
adenocard 14 30.16 Quite Low
Inflammation 6 8.24 Low Low
headache 11 5.00 Very Low Very Low Very Low
methotrexate 10 5.00 Very Low Very Low Very Low
abdominal pain 8 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tumor Lysis Syndrome 472 100.00 Very High Very High Very High
Hyperuricemia 252 99.90 Very High Very High Very High
Acute Renal Failure 109 99.04 Very High Very High Very High
Ring Chromosomes 9 99.04 Very High Very High Very High
Hypocalcemia 44 98.76 Very High Very High Very High
Toxicity 49 97.12 Very High Very High Very High
Crystal Associated Disease 49 96.96 Very High Very High Very High
Hematologic Neoplasms 30 96.88 Very High Very High Very High
Nephrocalcinosis 20 96.48 Very High Very High Very High
Solid Tumor 57 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, clinical data do not yet provide enough evidence to support replacing allopurinol with rasburicase as the standard of care in patients not at high risk of TLS or with laboratory TLS.
Gene_expression (risk) of TLS associated with tumor lysis syndrome
1) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 0.84 Pain Relevance 0.03
Pathogenesis of TLS
Gene_expression (Pathogenesis) of TLS associated with tumor lysis syndrome
2) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 2.89 Pain Relevance 0
Additionally, clinical data do not yet provide enough evidence to support replacing allopurinol with rasburicase as the standard of care in patients not at high risk of TLS or with laboratory TLS.
Gene_expression (risk) of TLS associated with tumor lysis syndrome
3) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 0.85 Pain Relevance 0.03
Prevention and therapy of TLS
Gene_expression (Prevention) of TLS associated with tumor lysis syndrome
4) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 1.44 Pain Relevance 0
Iatrogenic urine alkalinization in patients presenting TLS with hyperphosphatemia and/or hypocalcemia may be associated with an increased risk of nephrocalcinosis, and thus it must be avoided especially in patients whose calcium × phosphate product exceeds the solubility limit.
Gene_expression (presenting) of TLS in urine associated with iatrogenic, hypocalcemia, tumor lysis syndrome and nephrocalcinosis
5) Confidence 0.29 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 1.73 Pain Relevance 0.10
B Bicolor FISH with a FUS (16p11) spanning probe in Spectrum Green and a CREB3L2 (7q33) spanning probe in Spectrum Red demonstrates fusion of green and red signals (arrows) indicative of the t(7;16)(q33;p11) characteristic of low-grade fibromyxoid sarcoma
Gene_expression (16p11) of FUS associated with sarcoma
6) Confidence 0.22 Published 2008 Journal J Orthop Sci Section Body Doc Link PMC2778709 Disease Relevance 0.45 Pain Relevance 0
The classic approach to TLS fails in prevention of acute renal failure in over to 25% of patients. 42

Gout

Gene_expression (approach) of TLS associated with acute renal failure, crystal associated disease and tumor lysis syndrome
7) Confidence 0.13 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 2.04 Pain Relevance 0
Urate oxidase in the prophylaxis and treatment of hyperuricemia and TLS reduces metabolic and renal complications and need for dialysis, which is more frequent in patients who receive allopurinol than rasburicase (16% vs 2.6%). 27 Other studies do not correlate need for dialysis with use of rasburicase. 64,65 In Goldman's trial, among patients treated with rasburicase, none required dialysis. 14 Among 100 patients with non Hodgink lymphoma, treated with rasburicase, during the first cycle of chemotherapy, none required dialysis and normalization of uric acid levels and control of creatinine levels were achieved. 66
Gene_expression (reduces) of TLS associated with hyperuricemia, lymphatic system cancer and tumor lysis syndrome
8) Confidence 0.13 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.61 Pain Relevance 0
FUS-X is produced by different species of the genus F. graminearum, F. oxysporum, F. semitectum, F. sporotrichioides, F. sambucinum [117].


Gene_expression (produced) of FUS-X
9) Confidence 0.02 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635619 Disease Relevance 0.68 Pain Relevance 0

General Comments

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