INT205657

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 6.61
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FUS) cell death (FUS) nucleolus (FUS)
RNA binding (FUS) nucleus (FUS) intracellular (FUS)
FUS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 98.28 Very High Very High Very High
Onset of action 8 92.24 High High
Inflammation 4 38.32 Quite Low
adenocard 10 5.00 Very Low Very Low Very Low
headache 7 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
abdominal pain 5 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
intrathecal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tumor Lysis Syndrome 308 100.00 Very High Very High Very High
Cancer 99 98.88 Very High Very High Very High
Pain 2 98.28 Very High Very High Very High
Appetite Loss 4 98.04 Very High Very High Very High
Hypersensitivity 62 98.00 Very High Very High Very High
Hyperuricemia 176 96.96 Very High Very High Very High
Crystal Associated Disease 47 95.16 Very High Very High Very High
Congenital Anomalies 24 93.16 High High
Leukemia 39 91.68 High High
Adverse Drug Reaction 12 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this section we propose a possible therapeutic schema in adults and pediatric patient for prevention of TLS, according to risk group (Table 3) and for treatment of both for laboratory and clinical TLS (Table 4).
Negative_regulation (prevention) of TLS associated with tumor lysis syndrome
1) Confidence 0.21 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 1.56 Pain Relevance 0
At the present time, rasburicase provides an alternative for the prevention of TLS in patients at high risk and it is strongly suggested for the treatment of hyperuricemia and TLS.
Negative_regulation (prevention) of TLS associated with hyperuricemia and tumor lysis syndrome
2) Confidence 0.20 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 1.07 Pain Relevance 0.05
Recently Cairo and Bishop proposed a uniform definition of TLS, identifying a laboratory TLS (LTLS) and clinical TLS (CTLS).
Negative_regulation (definition) of TLS associated with tumor lysis syndrome
3) Confidence 0.20 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 1.35 Pain Relevance 0
It is an imperative treating or, better, preventing TLS, because each metabolic derangement is associated with remarkable clinical manifestations.
Negative_regulation (preventing) of TLS associated with tumor lysis syndrome
4) Confidence 0.12 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 1.47 Pain Relevance 0.10
Nevertheless, a limit of rasburicase's use remains its cost, which obliges to a judicious choice to prevent TLS in high risk patients with cancer and in case of allergy or impossibility to take allopurinol orally both in TLS and in gout.
Negative_regulation (prevent) of TLS associated with cancer, hypersensitivity, crystal associated disease and tumor lysis syndrome
5) Confidence 0.08 Published 2007 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC1838823 Disease Relevance 1.15 Pain Relevance 0

General Comments

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