INT205683

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.63
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
platelet 4
Ptafr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 128 100.00 Very High Very High Very High
cytokine 40 100.00 Very High Very High Very High
Inflammatory mediators 8 100.00 Very High Very High Very High
Serotonin 3 100.00 Very High Very High Very High
bradykinin 3 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Pain 26 93.76 High High
COX2 1 91.96 High High
cOX1 2 91.76 High High
Inflammatory response 9 89.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 142 100.00 Very High Very High Very High
Pressure And Volume Under Development 13 99.64 Very High Very High Very High
Inflammatory Bowel Disease 54 98.84 Very High Very High Very High
Immune System Diseases 2 96.92 Very High Very High Very High
Hypersensitivity 6 95.88 Very High Very High Very High
Apoptosis 43 95.28 Very High Very High Very High
Pain 27 93.76 High High
Nociception 11 92.96 High High
Fungal Infection 2 90.76 High High
Necrosis 7 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This enzyme family is comprised of approximately 15 groups and four main types, including the secreted sPLA2, cytosolic cPLA2, calcium-independent iPLA2, and platelet activating factor (PAF) [33].
Localization (secreted) of platelet activating factor in platelet
1) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.69 Pain Relevance 0.60
Carrageenan induces paw edema resulting in the release of mediators such as histamine, serotonin, bradykinin, substance P, platelet activating factor and prostaglandins [21–27].
Localization (release) of platelet activating factor in platelet associated with pressure and volume under development, bradykinin, serotonin and substance p
2) Confidence 0.06 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996782 Disease Relevance 0.93 Pain Relevance 0.80
In general, granulocytes are recruited to sites of inflammation where they release inflammatory mediators such as leukotriene B4, platelet activating factor and IL-8.
Localization (release) of platelet activating factor in platelet associated with inflammatory mediators and inflammation
3) Confidence 0.03 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 1.80 Pain Relevance 0.44
As in other inflammatory processes, IBD is characterized by an upregulation in the synthesis and release of different pro-inflammatory cytokines, including reactive oxygen and nitrogen metabolites, eicosanoids, platelet-activating factor, and cytokines (Stenson 1994).
Localization (release) of platelet-activating factor in platelet associated with inflammatory bowel disease, inflammation and cytokine
4) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721377 Disease Relevance 1.13 Pain Relevance 0.47

General Comments

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