INT205685

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.62
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
cleavage 2
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 2 99.90 Very High Very High Very High
Inflammation 89 92.00 High High
cytokine 40 89.28 High High
antagonist 23 78.48 Quite High
adenocard 45 75.80 Quite High
corticosteroid 4 68.48 Quite High
agonist 16 67.52 Quite High
cINOD 11 67.16 Quite High
Arthritis 25 58.20 Quite High
anakinra 24 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 115 99.74 Very High Very High Very High
Syndrome 4 88.48 High High
Crystal Associated Disease 76 88.08 High High
Cryopyrin-associated Periodic Syndromes 1 87.44 High High
Arthritis 22 75.48 Quite High
Gastrointestinal Disease 1 75.28 Quite High
Middle Cerebral Artery Infarction 5 70.72 Quite High
Apoptosis 46 59.92 Quite High
Infection 13 39.84 Quite Low
Death 31 37.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
maturation and release in this cell type involves an outwardly directed K+ conductance and the activation of interleukin-1 convertase enzyme (ICE, also known as caspase 1) responsible for the cleavage of pro-IL1?
Regulation (involves) of Positive_regulation (activation) of interleukin-1 convertase enzyme in cleavage
1) Confidence 0.11 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 0.07 Pain Relevance 0.11
These authors showed that the P2X7R is up-stream of the inflammasome, an important complex of cytosolic proteins that are known to regulate caspase-1 activation and ultimately the processing of IL-1?
Regulation (regulate) of Positive_regulation (activation) of caspase-1
2) Confidence 0.06 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.64 Pain Relevance 0.33
The inflammasome acts as an intracellular sensor of inflammatory stimuli and regulates the activation of caspase-1.
Regulation (regulates) of Positive_regulation (activation) of caspase-1 associated with inflammatory stimuli
3) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.91 Pain Relevance 0.34

General Comments

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