INT205690

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.26
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
Anatomy Link Frequency
macrophages 5
microglia 3
mast cells 2
neuronal 1
monocytes 1
P2rx7 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 120 100.00 Very High Very High Very High
Endocannabinoid 8 96.84 Very High Very High Very High
ischemia 14 93.32 High High
Multiple sclerosis 20 91.36 High High
antagonist 154 86.08 High High
Inflammation 512 83.68 Quite High
cytokine 487 77.00 Quite High
Inflammatory response 59 74.84 Quite High
Inflammatory mediators 50 71.36 Quite High
tolerance 2 68.48 Quite High
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 10 100.00 Very High Very High Very High
Targeted Disruption 56 99.96 Very High Very High Very High
Death 137 99.72 Very High Very High Very High
Apoptosis 226 99.00 Very High Very High Very High
Hypertension 2 97.28 Very High Very High Very High
Cv Unclassified Under Development 14 93.32 High High
Disease 158 92.32 High High
Demyelinating Disease 20 91.36 High High
Brain Injury 25 90.52 High High
Stroke 17 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bulanova et al. [25] have shown that addition of extracellular ATP in the millimolar range induced activation of P2X7 expressed on murine mast cells, resulting in the rapid but transient phosphorylation of ERK, Jak2 and STAT6.
Positive_regulation (induced) of Positive_regulation (activation) of P2X7 in mast cells
1) Confidence 0.68 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.44 Pain Relevance 0.13
has been reported to induce COX-2 in various tissues including glia, it has been proposed that a vicious cycle occurs whereby ATP release (from cell death for example) leads to P2X7R activation, IL-1?
Positive_regulation (leads) of Positive_regulation (activation) of P2X7R associated with death
2) Confidence 0.49 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 1.10 Pain Relevance 0.20
With high concentrations (0.5–5 mM) of ATP required for optimal activation of P2X7R-mediated IL-1?
Positive_regulation (required) of Positive_regulation (activation) of P2X7R-mediated
3) Confidence 0.49 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.32 Pain Relevance 0.07
These results suggested two other possibilities: that P2X7R channel activation induces a distinct signal transduction pathway which leads to dye uptake [41], or a distinct P2X7R-interacting protein is the dye uptake pathway [39].


Positive_regulation (induces) of Positive_regulation (activation) of P2X7R
4) Confidence 0.46 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
release induced by P2X7R and panx1 activation.
Positive_regulation (induced) of Positive_regulation (activation) of P2X7R
5) Confidence 0.46 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
It has now been demonstrated that P2X7 receptor activation of caspase-1 is dependent on the pre-stimulation of macrophages with microbially derived ligands for Toll-like receptors (TLR2/4/9) such as LPS and is dependent on de novo protein synthesis (cyclohexamide blocks the ability of LPS to prime cells for P2X7-dependent caspase-1 activation) via the NF-kB pathway (Kahlenberg et al. [21]).
Positive_regulation (dependent) of Positive_regulation (activation) of P2X7 receptor in macrophages
6) Confidence 0.46 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.28 Pain Relevance 0.16
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Positive_regulation (confirmed) of Positive_regulation (using) of P2X7R associated with targeted disruption
7) Confidence 0.43 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.83 Pain Relevance 0.13
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Positive_regulation (-) of Positive_regulation (activation) of P2X7R associated with targeted disruption
8) Confidence 0.43 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.79 Pain Relevance 0.13
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Positive_regulation (inducing) of Positive_regulation (activation) of P2X7R associated with targeted disruption
9) Confidence 0.43 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.79 Pain Relevance 0.13
Signaling pathways associated with P2X7 receptor activation Mechanistic elements engaged as a result of P2X7 receptor activation that are responsible for initiating IL-1?
Positive_regulation (responsible) of Positive_regulation (activation) of P2X7 receptor
10) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0
Signaling pathways associated with P2X7 receptor activation Mechanistic elements engaged as a result of P2X7 receptor activation that are responsible for initiating IL-1?
Positive_regulation (result) of Positive_regulation (activation) of P2X7 receptor
11) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0
Similarly, K+ efflux mediated via P2X7 receptor activation in LPS-stimulated monocytes and macrophages is necessary for efficient IL-1?
Positive_regulation (mediated) of Positive_regulation (activation) of P2X7 receptor in macrophages
12) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0
Finally, activation of P2X7 receptors by low concentration of agonists stimulates the release of the neuroprotective mediator plasminogen from cultured microglia [74].
Positive_regulation (stimulates) of Positive_regulation (activation) of P2X7 in microglia associated with agonist
13) Confidence 0.18 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 0.12 Pain Relevance 0.22
In a more recent study, an early (1 day after MCAO occlusion) upregulation of the P2X7 receptor protein was observed in microglial cells, and later (4– days after MCAO occlusion), the receptor was also overexpressed in neurons and astrocytes of the periinfarct area in spontaneously hypertensive rats, as revealed by co-localization studies with neuronal, astroglial and microglial markers [81].
Positive_regulation (overexpressed) of in neuronal Positive_regulation (upregulation) of P2X7 receptor protein in microglial cells associated with middle cerebral artery infarction and hypertension
14) Confidence 0.17 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 1.59 Pain Relevance 0.11
Similarly, K+ efflux mediated via P2X7 receptor activation in LPS-stimulated monocytes and macrophages is necessary for efficient IL-1?
Positive_regulation (mediated) of in monocytes Positive_regulation (activation) of P2X7 receptor in macrophages
15) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0

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