INT205691

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.25
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
Anatomy Link Frequency
macrophages 4
joints 2
P2rx7 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 12 99.88 Very High Very High Very High
Inflammation 182 96.04 Very High Very High Very High
antagonist 50 95.28 Very High Very High Very High
agonist 46 90.48 High High
cytokine 216 89.76 High High
Inflammatory mediators 22 77.28 Quite High
Neuropathic pain 17 74.32 Quite High
Inflammatory stimuli 5 68.76 Quite High
ischemia 7 66.08 Quite High
Inflammatory response 25 64.96 Quite High
Disease Link Frequency Relevance Heat
Arthritis 15 99.88 Very High Very High Very High
Alzheimer's Dementia 3 97.12 Very High Very High Very High
INFLAMMATION 227 96.04 Very High Very High Very High
Targeted Disruption 27 96.04 Very High Very High Very High
Amyloid Plaque 2 93.52 High High
Hypertension 1 82.08 Quite High
Middle Cerebral Artery Infarction 5 76.96 Quite High
Neuropathic Pain 31 74.32 Quite High
Asthma 3 70.56 Quite High
Immune System Diseases 4 70.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therapies directed at influencing the P2X7R
Regulation (directed) of Gene_expression (influencing) of P2X7R
1) Confidence 0.44 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 1.16 Pain Relevance 0.45
This showed that whilst in the wild-type mice all joints subjected to mAb-induced arthritis were affected, the P2X7 ????
Regulation (affected) of Gene_expression (???) of P2X7 in joints associated with arthritis
2) Confidence 0.39 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.52 Pain Relevance 0.23
The behavioural phenotype of the P2X7 ????
Regulation (phenotype) of Gene_expression (???) of P2X7
3) Confidence 0.39 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.58 Pain Relevance 0.23
P2X7 receptor-mediated effects As noted earlier, the P2X7 receptor is present on a number of leukocyte populations including monocytes and tissue macrophages.
Regulation (effects) of Gene_expression (present) of P2X7 receptor in macrophages
4) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.10 Pain Relevance 0.45
when treated with the potassium ionophore nigericin, indicating that the P2X7 receptor-deficient macrophages are competent to process proIL-1?
Regulation (competent) of Gene_expression (macrophages) of P2X7 receptor-deficient in macrophages
5) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0
Altogether, these data indicate that the expression of P2X7 receptors is strongly activity-dependent during pathological situations.
Regulation (dependent) of Gene_expression (expression) of P2X7
6) Confidence 0.10 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 0.89 Pain Relevance 0.06

General Comments

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