INT205692

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.00
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
tibia 2
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 9 99.96 Very High Very High Very High
Nerve growth factor 46 99.46 Very High Very High Very High
reflex sympathetic dystrophy 6 99.28 Very High Very High Very High
Trk A 11 98.64 Very High Very High Very High
Inflammation 232 98.36 Very High Very High Very High
antagonist 32 95.76 Very High Very High Very High
Antinociceptive 4 93.88 High High
Lasting pain 1 85.84 High High
Dorsal horn 1 84.76 Quite High
Spinal cord 8 84.28 Quite High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 6 98.96 Very High Very High Very High
INFLAMMATION 271 98.36 Very High Very High Very High
Bone Fracture 6 97.20 Very High Very High Very High
Targeted Disruption 19 96.76 Very High Very High Very High
Disease 25 94.76 High High
Infection 46 92.08 High High
Apoptosis 43 91.08 High High
Pain 37 85.84 High High
Diabetes Mellitus 45 84.88 Quite High
Neuropathic Pain 66 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, the NALP1 inflammasome is required for caspase-1 activation and mediates the complex regional pain syndrome that developed after tibia fracture in rats [18].
Positive_regulation (required) of Positive_regulation (activation) of caspase-1 in tibia associated with complex regional pain syndromes, bone fracture and reflex sympathetic dystrophy
1) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.88 Pain Relevance 0.52
Collectively, these data suggest that NALP3 is the inflammasome that triggers caspase-1 activation in the mediation of carrageenin-induced inflammatory hypernociception, yet other inflammasomes could be also involved.
Positive_regulation (triggers) of Positive_regulation (activation) of caspase-1 associated with inflammation
2) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.73 Pain Relevance 0.41
To date the proteins that facilitate efficient coupling of caspase-1 activation to P2X7 stimulation are unclear but their identification may provide interesting alternative therapeutic targets for inflammatory diseases.
Positive_regulation (facilitate) of Positive_regulation (activation) of caspase-1 associated with inflammation and disease
3) Confidence 0.13 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.38 Pain Relevance 0.15
LL-37 has now been shown to induce caspase-1 activation and secretion of mature IL-1?
Positive_regulation (induce) of Positive_regulation (activation) of caspase-1
4) Confidence 0.11 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.26 Pain Relevance 0.11
There are two potential signaling mechanisms that may underlie this effect: 1) NGF may directly induce Trk A-dependent p38 phosphorylation, or 2) NGF could indirectly activate interleukin 1-beta-dependent p38 activation to promote SP expression [36].
Positive_regulation (promote) of Positive_regulation (activation) of interleukin 1-beta-dependent associated with nerve growth factor, trk a and substance p
5) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.66 Pain Relevance 1.15
Two caspase-1 molecules are then recruited and activated by the complex which then leads to the activation of caspase-1 and subsequent IL-1?
Positive_regulation (leads) of Positive_regulation (activation) of caspase-1
6) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.09 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox