INT205702

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.38
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
P2rx7 (Mus musculus)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 132 100.00 Very High Very High Very High
cytokine 54 100.00 Very High Very High Very High
antagonist 40 81.52 Quite High
agonist 20 27.80 Quite Low
Central nervous system 4 17.92 Low Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
rheumatoid arthritis 14 5.00 Very Low Very Low Very Low
Inflammatory mediators 12 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 158 100.00 Very High Very High Very High
Syndrome 2 91.52 High High
Cryopyrin-associated Periodic Syndromes 2 90.48 High High
Arthritis 6 88.76 High High
Apoptosis 80 73.20 Quite High
Infection 18 53.12 Quite High
Death 50 5.00 Very Low Very Low Very Low
Mycobacterial Infection 34 5.00 Very Low Very Low Very Low
Cancer 26 5.00 Very Low Very Low Very Low
Disease 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These authors showed that the P2X7R is up-stream of the inflammasome, an important complex of cytosolic proteins that are known to regulate caspase-1 activation and ultimately the processing of IL-1?
P2X7R Regulation (regulate) of Gene_expression (processing) of IL-1
1) Confidence 0.04 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.67 Pain Relevance 0.34
The importance of, and the mechanisms through which the P2X7R regulates the production of the pro-inflammatory cytokines IL-1?
P2X7R Regulation (regulates) of Gene_expression (production) of IL-1 associated with inflammation and cytokine
2) Confidence 0.02 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.71 Pain Relevance 0.33

General Comments

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