INT205703

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (P2rx7, Casp1) cytoplasm (P2rx7, Casp1) cell death (P2rx7, Casp1)
transport (P2rx7) cell morphogenesis (P2rx7) intracellular (Casp1)
P2rx7 (Mus musculus)
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 27 93.32 High High
Inflammation 66 92.92 High High
antagonist 20 78.48 Quite High
agonist 10 18.56 Low Low
Central nervous system 2 14.88 Low Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 79 92.92 High High
Syndrome 1 88.48 High High
Cryopyrin-associated Periodic Syndromes 1 87.44 High High
Arthritis 3 79.52 Quite High
Apoptosis 40 63.96 Quite High
Infection 9 43.88 Quite Low
Death 25 5.00 Very Low Very Low Very Low
Mycobacterial Infection 17 5.00 Very Low Very Low Very Low
Cancer 13 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These authors showed that the P2X7R is up-stream of the inflammasome, an important complex of cytosolic proteins that are known to regulate caspase-1 activation and ultimately the processing of IL-1?
P2X7R Regulation (regulate) of Positive_regulation (activation) of caspase-1
1) Confidence 0.11 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.66 Pain Relevance 0.33

General Comments

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