INT205706

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.35
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (P2rx7, Il18) transport (P2rx7) cell morphogenesis (P2rx7)
mitochondrion organization (P2rx7) protein complex (P2rx7) transmembrane transport (P2rx7)
P2rx7 (Mus musculus)
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 54 100.00 Very High Very High Very High
Pain 2 99.00 Very High Very High Very High
Multiple sclerosis 8 98.20 Very High Very High Very High
Arthritis 4 96.96 Very High Very High Very High
agonist 20 85.24 High High
Inflammation 132 73.00 Quite High
antagonist 40 47.12 Quite Low
Inflammatory response 14 5.20 Low Low
rheumatoid arthritis 14 5.00 Very Low Very Low Very Low
Inflammatory mediators 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 99.00 Very High Very High Very High
Hepatitis 2 98.64 Very High Very High Very High
Demyelinating Disease 8 98.20 Very High Very High Very High
Arthritis 6 96.96 Very High Very High Very High
Targeted Disruption 12 92.60 High High
INFLAMMATION 158 73.00 Quite High
Disease 24 67.60 Quite High
Injury 10 11.36 Low Low
Mycobacterial Infection 34 7.32 Low Low
Atherosclerosis 6 6.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
secretion, the P2X7R has been implicated in the synthesis and release of the related leaderless cytokine IL-18 (interferon-?
P2X7R Regulation (implicated) of Gene_expression (synthesis) of IL-18 associated with cytokine
1) Confidence 0.21 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.67 Pain Relevance 0.35
The role of P2X7R in IL-18 production
P2X7R Regulation (role) of Gene_expression (production) of IL-18
2) Confidence 0.21 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.69 Pain Relevance 0.35

General Comments

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