INT20575

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 48
Total Number 54
Disease Relevance 6.20
Pain Relevance 22.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Akr1d1) oxidoreductase activity (Akr1d1) cytoplasm (Akr1d1)
Anatomy Link Frequency
neurons 9
striatum 8
whisker 8
basal ganglia 2
plasma 1
Akr1d1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 779 100.00 Very High Very High Very High
dopamine receptor 151 100.00 Very High Very High Very High
agonist 140 100.00 Very High Very High Very High
antagonist 112 100.00 Very High Very High Very High
Nucleus accumbens 85 100.00 Very High Very High Very High
Enkephalin 62 100.00 Very High Very High Very High
Neuropeptide 13 100.00 Very High Very High Very High
mu opioid receptor 4 100.00 Very High Very High Very High
Delta opioid receptors 9 99.66 Very High Very High Very High
antidepressant 8 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypothermia 3 99.98 Very High Very High Very High
Aids-related Complex 60 99.92 Very High Very High Very High
Cv General 2 Under Development 1 99.90 Very High Very High Very High
Stress 37 98.04 Very High Very High Very High
Arthritis 3 94.64 High High
Fever 3 93.84 High High
Synovitis 2 92.64 High High
Movement Disorders 3 91.92 High High
Pressure And Volume Under Development 2 91.08 High High
Congenital Anomalies 7 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The D1 and D2 genes are the most widely expressed in the caudate-putamen, the accumbens nucleus, and the olfactory tubercle.
Gene_expression (expressed) of D1 in caudate-putamen associated with nucleus accumbens
1) Confidence 0.57 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.29
D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum.
Gene_expression (expression) of D1 in striatum associated with dopamine receptor
2) Confidence 0.57 Published 1995 Journal J. Comp. Neurol. Section Title Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.29
Our study was undertaken in order to analyze in detail the expression of the D1 and D2 receptor genes in the efferent striatal populations, with special reference to the various striatal areas, and to yield insights into the question about D1 and D2 mRNA localization in the striatum.
Spec (analyze) Gene_expression (expression) of D1 in striatum
3) Confidence 0.57 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.41
These results confirm that the D1 and D2 receptor genes are expressed in distinct populations of striatal efferent neurons in the normal adult rat.
Gene_expression (expressed) of D1 in efferent neurons
4) Confidence 0.57 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7636023 Disease Relevance 0 Pain Relevance 0.31
This was true for both arc 1 (D1 and C1) whiskers, and arc 2 (D2 and C2) whiskers.
Gene_expression (whiskers) of D1 in whiskers associated with aids-related complex
5) Confidence 0.34 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0.33 Pain Relevance 0
On frozen slices, dopaminergic D1 and D2 receptors were stained immunohistochemically using monoclonal antibodies. 4.
Gene_expression (stained) of D1
6) Confidence 0.30 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15008964 Disease Relevance 0 Pain Relevance 0.16
This result is shown for D1 and D3 whiskers of rat N1 in Figure 9C, and for all whiskers in Figure 9D.
Gene_expression (whiskers) of D1 in whiskers
7) Confidence 0.30 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0 Pain Relevance 0
We repeated this analysis for ten whiskers (five D1 whiskers, four D2 whiskers, and one D3 whisker) in five rats (N4–N6, H1, and H2).
Gene_expression (whiskers) of D1 in whisker
8) Confidence 0.30 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0 Pain Relevance 0
This was particularly evident for the D1 whisker in rat N2 and the ?
Gene_expression (whisker) of D1 in whisker
9) Confidence 0.30 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0 Pain Relevance 0
Examples are shown in Figure 3C for the D1 whisker (length: 38.7 mm, FRF: 44.1 Hz) and D2 whisker (length: 31.6 mm, FRF: 60.5 Hz) from rat N2 (same whiskers as for the power spectra in Figure 3A).
Gene_expression (whisker) of D1 in whisker
10) Confidence 0.30 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0 Pain Relevance 0
In rat N2, the D2 and D1 whiskers were trimmed by approximately 2 mm after each day's measurement, while ?
Gene_expression (whiskers) of D1 in whiskers
11) Confidence 0.30 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0.07 Pain Relevance 0
This measurement was performed for the D1 and D2 whiskers in three rats (N6: 89–103 trials per texture, H1: 52–56 trials per texture, and H2: 40–43 trials per texture).
Gene_expression (whiskers) of D1 in whiskers
12) Confidence 0.30 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0 Pain Relevance 0.13
Drugs selective for the dopamine D1 and D2 receptors, respectively, as well as unselective drugs were used.
Gene_expression (selective) of D1 associated with dopamine
13) Confidence 0.13 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2444900 Disease Relevance 0 Pain Relevance 0.97
It is concluded that stimulation of delta-opioid receptors facilitates the expression of D1 and D2 responses arising from the denervated striatum.
Gene_expression (expression) of D1 in striatum associated with delta opioid receptors
14) Confidence 0.09 Published 1998 Journal Behav Pharmacol Section Abstract Doc Link 9832944 Disease Relevance 0 Pain Relevance 0.34
The consequences of irreversibly-inhibiting D2 dopaminergic receptors on the expression of D1 and D2 dopamine receptor mRNAs and proenkephalin mRNA and on the levels of mu- and delta-opioid receptors in rat striatum were studied following single or repeated administration of the irreversibly-acting D2 dopamine receptor antagonist, fluphenazine-N-mustard (FNM).
Gene_expression (expression) of D1 in striatum associated with antagonist, dopamine receptor and delta opioid receptors
15) Confidence 0.06 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7820070 Disease Relevance 0 Pain Relevance 0.48
Febrile response was present only on D1.
Gene_expression (present) of D1 associated with cv general 2 under development
16) Confidence 0.05 Published 1994 Journal Life Sci. Section Abstract Doc Link 7934634 Disease Relevance 0.76 Pain Relevance 0.19
In situ hybridization histochemistry was used either in combination with retrograde labeling of striatonigral neurons to determine the projection site of A2a receptor expressing neurons, or on consecutive thin sections to address the putative coexpression of the A2a receptor with the D1 or D2 receptors in individual neurons.
Gene_expression (coexpression) of D1 in neurons
17) Confidence 0.05 Published 1993 Journal J. Neurosci. Section Abstract Doc Link 7680065 Disease Relevance 0.05 Pain Relevance 0.51
These data imply that dopamine in the nucleus accumbens may act on each population of efferent neurons via the co-expression of two distinct dopamine receptors (D1+D3 or D2+D3), and that synergistic D1-like/D2-like effects may occur at the level of a single neuron, through the co-expression of D1 and D3 receptors in a significant proportion of substance P neurons (16% or 26% in the core and shell regions, respectively.
Gene_expression (co-expression) of D1 in neuron associated with nucleus accumbens, dopamine, dopamine receptor and substance p
18) Confidence 0.05 Published 1996 Journal Neuroscience Section Abstract Doc Link 8783237 Disease Relevance 0 Pain Relevance 0.57
These results suggest that persistent inhibition of D2 dopamine receptors differentially regulates the expression of D1 and D2 dopamine receptor mRNA in striatum, and that the magnitude, duration and interval of inhibiting dopaminergic transmission may be important factors in regulating dopamine receptor mRNA expression.
Gene_expression (expression) of D1 in striatum associated with dopamine receptor
19) Confidence 0.05 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7820070 Disease Relevance 0 Pain Relevance 0.93
In addition, comparison with D1 and D2 receptor gene expression was performed to study the potential co-localization of several dopamine receptors within the same neurons in the ventral striatum.
Gene_expression (expression) of D1 in ventral associated with dopamine receptor
20) Confidence 0.05 Published 1996 Journal Neuroscience Section Abstract Doc Link 8783237 Disease Relevance 0 Pain Relevance 0.51

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