INT205754

Context Info Confidence 0.75 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.24 Pain Relevance 0

mitosis (Dctn3) chromosome (Dctn3) cytoskeleton (Dctn3) cell cycle (Dctn3) molecular_function (Dctn3) cell division (Dctn3)

Anatomy Link Frequency lymphocytes 2 Dctn3 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 16 5.00 iatrogenic 4 5.00 palliative 2 5.00 Central nervous system 2 5.00 Inflammation 2 5.00 Bioavailability 2 5.00 metalloproteinase 2 5.00 Kinase C 2 5.00 Potency 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 36 99.20 Disease 38 86.80 Death 20 72.44 Leukemia 30 68.72 Chronic Lymphoid Leukemia 8 67.60 Cancer 44 62.16 Lymphocytosis 66 58.64 Enzootic Bovine Leukosis 26 50.00 Viral Infection 12 49.56 Infection 52 10.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For instance, when lymphocytes are isolated from a BLV-infected sheep and maintained for a few hours in culture, almost all cells expressing the major viral capsid protein p24gag fail to undergo apoptosis (Figure 4).

Gene_expression (expressing) of p24 in lymphocytes associated with apoptosis

1) Confidence 0.75 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.67 Pain Relevance 0

Since lymphocytes synthesizing p24gag are spared from apoptosis ex vivo, p24+BrdU+ double positive cells are not lost during culturing but appear to have been eliminated in vivo.

Gene_expression (synthesizing) of p24 in lymphocytes associated with apoptosis

2) Confidence 0.65 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.57 Pain Relevance 0

General Comments

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