INT20579

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Context Info
Confidence 0.04
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 2.91
Pain Relevance 8.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Akr1d1) oxidoreductase activity (Akr1d1) cytoplasm (Akr1d1)
Anatomy Link Frequency
striatum 2
cingulate cortex 1
brains 1
forebrain 1
midbrain 1
Akr1d1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 94 100.00 Very High Very High Very High
dopamine receptor 39 100.00 Very High Very High Very High
Cholecystokinin 6 100.00 Very High Very High Very High
Anterior cingulate cortex 2 99.80 Very High Very High Very High
Inflammation 52 99.48 Very High Very High Very High
Opioid 3 99.32 Very High Very High Very High
Nucleus accumbens 13 99.20 Very High Very High Very High
substance P 4 99.08 Very High Very High Very High
opioid receptor 3 98.96 Very High Very High Very High
cocaine 28 98.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 52 99.48 Very High Very High Very High
Eating Disorder 3 98.48 Very High Very High Very High
Stress 7 98.04 Very High Very High Very High
Nociception 26 95.56 Very High Very High Very High
Hyperkinesis 1 88.64 High High
Pain 40 84.40 Quite High
Neuropathic Pain 4 82.52 Quite High
Disease 4 81.44 Quite High
Dyskinesias 1 75.00 Quite High
Morphine Dependence 2 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present animal model, cocaine exposure in utero had no significant effect on mRNA levels of the dopamine transporter, D1 or D2 dopamine receptors, enkephalin, tyrosine hydroxylase, or cholecystokinin in juvenile rats.
Transcription (levels) of D1 in juvenile associated with dopamine, dopamine receptor, enkephalin, cholecystokinin and cocaine
1) Confidence 0.04 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7909578 Disease Relevance 0.08 Pain Relevance 0.73
In abstinent rats, both D1- and D2-dopamine receptor mRNA levels were decreased 1 day after withdrawal (-30% compared with chronic morphine).
Transcription (levels) of D1 associated with dopamine receptor, withdrawal and morphine
2) Confidence 0.04 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10051749 Disease Relevance 0.13 Pain Relevance 1.63
The density of dopamine and opioid receptors was determined by receptor autoradiography and the levels of the mRNA for the D1 and D2 dopamine receptors and proenkephalin were measured by in situ hybridization histochemistry.
Transcription (levels) of D1 associated with dopamine, dopamine receptor and opioid receptor
3) Confidence 0.04 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7820070 Disease Relevance 0 Pain Relevance 0.72
Levels of mRNA for the dopamine transporter, tyrosine hydroxylase, cholecystokinin, D1 and D2 dopamine receptors and enkephalin were quantitated in relevant dopaminergic regions of forebrain and midbrain of offspring that were sacrificed on postnatal day 21.
Transcription (Levels) of D1 in forebrain associated with dopamine, dopamine receptor, midbrain, enkephalin and cholecystokinin
4) Confidence 0.03 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7909578 Disease Relevance 0.10 Pain Relevance 0.71
Conversely, striatonigral neurons show a 6-OHDA-induced reduction in their specific expression of mRNAs encoding the D1 dopamine receptor and substance P, which is reversed by subsequent daily injections of the D1 agonist SKF-38393.
Transcription (expression) of D1 in neurons associated with dopamine receptor, agonist and substance p
5) Confidence 0.03 Published 1990 Journal Science Section Abstract Doc Link 2147780 Disease Relevance 0.23 Pain Relevance 0.65
In the present study, the mRNA expression of the dopamine receptors, D1 and D2, and the opioid peptides, prodynorphin and proenkephalin, were analyzed in the rat striatum using in situ hybridization histochemistry.
Spec (analyzed) Transcription (expression) of D1 in striatum associated with dopamine receptor and opioid
6) Confidence 0.02 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602109 Disease Relevance 0 Pain Relevance 0.62
Striatonigral and striatopallidal neurons were assessed using in situ hybridization histochemistry for mRNA levels of D1 and D2 dopamine receptors, preproenkephalin (ENK), prodynorphin (DYN), protachykinin (substance P), and glutamate decarboxylase (GAD67) in the dorsolateral and ventromedial striatum as well as the nucleus accumbens.
Transcription (levels) of D1 in striatum associated with nucleus accumbens, glutamate, dopamine receptor and substance p
7) Confidence 0.01 Published 1994 Journal Synapse Section Abstract Doc Link 7531873 Disease Relevance 0.16 Pain Relevance 0.37
Levels of mRNA for the dopamine transporter, tyrosine hydroxylase, cholecystokinin, D1 and D2 dopamine receptors and enkephalin were quantitated in relevant dopaminergic regions of forebrain and midbrain of offspring that were sacrificed on postnatal day 21.
Transcription (Levels) of D1 in midbrain associated with dopamine, dopamine receptor, midbrain, enkephalin and cholecystokinin
8) Confidence 0.01 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7909578 Disease Relevance 0.10 Pain Relevance 0.71
No differences were found between sham and lesion groups for ENK, D1, SubP, or GAD65 mRNA levels in the striatum or nucleus accumbens (NAC).
Transcription (levels) of D1 in nucleus accumbens associated with nucleus accumbens
9) Confidence 0.01 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630515 Disease Relevance 0 Pain Relevance 0.35
This study used in-situ hybridization to examine D1 and D2 receptor mRNA expression in the brains of rats subjected to chronic mild stress and/or chronic treatment (5 weeks) with the antidepressant drugs imipramine and fluoxetine.
Spec (examine) Transcription (expression) of D1 in brains associated with stress, antidepressant and fluoxetine
10) Confidence 0.01 Published 1997 Journal Behav Pharmacol Section Abstract Doc Link 9832973 Disease Relevance 0.40 Pain Relevance 0.43
Also, mRNA levels of D1 and D2R's were measured in the IC after three hours of inflammation.


Transcription (levels) of D1 associated with inflammation
11) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2994804 Disease Relevance 0.88 Pain Relevance 0.64
Similar findings were described in the anterior cingulate cortex with the expression of mRNA of dopaminergic D1 and D2 receptors [32].
Transcription (expression) of D1 in cingulate cortex associated with anterior cingulate cortex
12) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2994804 Disease Relevance 0.83 Pain Relevance 0.80

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