INT20585

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1990
Last Reported 2010
Negated 0
Speculated 14
Reported most in Abstract
Documents 39
Total Number 53
Disease Relevance 26.94
Pain Relevance 26.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra1)
Anatomy Link Frequency
brainstem 7
frontal cortex 7
spinal cord 5
hippocampus 4
IB4 3
Gfra1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 6 99.86 Very High Very High Very High
electroacupuncture 34 99.84 Very High Very High Very High
Spinal cord 79 99.64 Very High Very High Very High
Neuropathic pain 64 99.64 Very High Very High Very High
neuralgia 13 99.62 Very High Very High Very High
antidepressant 16 99.60 Very High Very High Very High
Nerve growth factor 109 99.56 Very High Very High Very High
Calcitonin gene-related peptide 105 99.54 Very High Very High Very High
Somatostatin 15 99.24 Very High Very High Very High
fluoxetine 8 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 88 99.96 Very High Very High Very High
Injury 115 99.88 Very High Very High Very High
Ganglion Cysts 107 99.84 Very High Very High Very High
Nociception 23 99.84 Very High Very High Very High
Contusions 13 99.74 Very High Very High Very High
Neuropathic Pain 64 99.64 Very High Very High Very High
Tooth Injuries 6 99.50 Very High Very High Very High
Frailty 14 98.88 Very High Very High Very High
Urological Neuroanatomy 38 98.56 Very High Very High Very High
Hyperalgesia 26 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expressions of both GDNF and GDNFR-alpha in the frontal cortex were decreased by treatment with MK801 (0.5 mg/kg), and the expressions of GDNF in both the stem and cortex, and GDNFR-beta in the brainstem decreased by treatment with the methyl-scopolamine (0.5 mg/kg).
Gene_expression (expressions) of GDNFR-alpha in brainstem
1) Confidence 0.77 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.13 Pain Relevance 0
The expressions of both GDNF and GDNFR-alpha in the frontal cortex were decreased by treatment with MK801 (0.5 mg/kg), and the expressions of GDNF in both the stem and cortex, and GDNFR-beta in the brainstem decreased by treatment with the methyl-scopolamine (0.5 mg/kg).
Gene_expression (expressions) of GDNFR-beta in brainstem
2) Confidence 0.77 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.12 Pain Relevance 0
OBJECTIVE: To investigate the expression of glial cell derived neurotrophic factor (GDNF) and its receptor GDNFR-alpha (GFRalpha-1) and GDNFR-beta (Ret) genes and the effects of muscarinic receptor antagonists, NMDA receptor antagonist, inhibitor of nitric oxide synthase on the expression of these genes in the spinal cord, brainstem and frontal cortex during morphine withdrawal, and to observe the effects of GDNF antisense oligoneucleotide (i.c.v) on the morphine withdrawal symptoms in rats.
Spec (investigate) Gene_expression (expression) of GFRalpha-1 in spinal cord associated with medulla, nmda receptor antagonist, antagonist, urological neuroanatomy, withdrawal, morphine and spinal cord
3) Confidence 0.77 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 11798749 Disease Relevance 0.25 Pain Relevance 0.65
The pre-treatment with L-N-nitric arginine methylester (10 mg/kg), the expressions of GDNF and GDNFR-beta in the spinal cord, both GDNFR-alpha and GDNFR-beta in the frontal cortex were decreased.
Gene_expression (expressions) of GDNFR-beta in frontal cortex
4) Confidence 0.77 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.14 Pain Relevance 0
The pre-treatment with L-N-nitric arginine methylester (10 mg/kg), the expressions of GDNF and GDNFR-beta in the spinal cord, both GDNFR-alpha and GDNFR-beta in the frontal cortex were decreased.
Gene_expression (expressions) of GDNFR-beta in frontal cortex
5) Confidence 0.77 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.14 Pain Relevance 0
[The expression of glial cell derived neurotrophic factor and its receptor GDNFR-alpha and GDNFR-beta mRNA in spinal cord, brainstem and frontal cortex during morphine withdrawal in rats].
Gene_expression (expression) of GDNFR-beta in spinal cord associated with medulla, urological neuroanatomy, withdrawal, morphine and spinal cord
6) Confidence 0.77 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Title Doc Link 11798749 Disease Relevance 0.10 Pain Relevance 0.66
Using immunohistochemistry, Western blot, and RT-PCR analysis techniques, the present study observed the effects of EA on the expression of GDNF and GDNF family receptor alpha-1 (GFRalpha-1, the high-affinity receptor of GDNF) in neuropathic pain rats.
Gene_expression (expression) of GFRalpha-1 associated with neuropathic pain and electroacupuncture
7) Confidence 0.73 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.84 Pain Relevance 1.23
[The expression of glial cell derived neurotrophic factor and its receptor GDNFR-alpha and GDNFR-beta mRNA in spinal cord, brainstem and frontal cortex during morphine withdrawal in rats].
Gene_expression (expression) of receptor GDNFR-alpha in spinal cord associated with medulla, urological neuroanatomy, withdrawal, morphine and spinal cord
8) Confidence 0.67 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Title Doc Link 11798749 Disease Relevance 0.10 Pain Relevance 0.66
OBJECTIVE: To investigate the expression of glial cell derived neurotrophic factor (GDNF) and its receptor GDNFR-alpha (GFRalpha-1) and GDNFR-beta (Ret) genes and the effects of muscarinic receptor antagonists, NMDA receptor antagonist, inhibitor of nitric oxide synthase on the expression of these genes in the spinal cord, brainstem and frontal cortex during morphine withdrawal, and to observe the effects of GDNF antisense oligoneucleotide (i.c.v) on the morphine withdrawal symptoms in rats.
Spec (investigate) Gene_expression (expression) of receptor GDNFR-alpha in spinal cord associated with medulla, nmda receptor antagonist, antagonist, urological neuroanatomy, withdrawal, morphine and spinal cord
9) Confidence 0.67 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 11798749 Disease Relevance 0.25 Pain Relevance 0.64
The influence of both acute and chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of mRNAs encoding glial cell line-derived neurotrophic factor (GDNF) and its receptors, GFRalpha-1, GFRalpha-2, and c-Ret proto-oncogene (RET) in the rat hippocampus was examined by in situ hybridization.
Spec (examined) Gene_expression (expression) of GFRalpha-1 in hippocampus associated with antidepressant, convulsion and hippocampus
10) Confidence 0.64 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.57 Pain Relevance 0.10
The results demonstrate that acute ECS increases the expression of GFRalpha-1 and GFRalpha-2 and that these effects are enhanced by chronic ECS.
Gene_expression (expression) of GFRalpha-1 associated with convulsion
11) Confidence 0.64 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.70 Pain Relevance 0.26
The results demonstrate that acute ECS increases the expression of GFRalpha-1 and GFRalpha-2 and that these effects are enhanced by chronic ECS.
Gene_expression (expression) of GFRalpha-2 associated with convulsion
12) Confidence 0.64 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.70 Pain Relevance 0.26
Chronic (once daily for 10 days) ECS significantly increased the expression of GFRalpha-1 mRNA nearly 5-fold after the last treatment.
Gene_expression (expression) of GFRalpha-1 mRNA associated with convulsion
13) Confidence 0.64 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.75 Pain Relevance 0.19
The influence of both acute and chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of mRNAs encoding glial cell line-derived neurotrophic factor (GDNF) and its receptors, GFRalpha-1, GFRalpha-2, and c-Ret proto-oncogene (RET) in the rat hippocampus was examined by in situ hybridization.
Spec (examined) Gene_expression (expression) of GFRalpha-2 in hippocampus associated with antidepressant, convulsion and hippocampus
14) Confidence 0.64 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.57 Pain Relevance 0.10
In the present work, we first examined c-ret and GDNF receptor alpha 1 (GFR-alpha 1) expression using an RNAse protection assay, and found that both receptors are expressed in the adult rat striatum.
Spec (examined) Gene_expression (expression) of GFR-alpha 1 in striatum
15) Confidence 0.62 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 9987028 Disease Relevance 0.15 Pain Relevance 0.04
CGRP fibers decreased, but GFRalpha1, GFRalpha2 and GFRalpha3 fibers did not change.
Gene_expression (fibers) of GFRalpha1 associated with calcitonin gene-related peptide
16) Confidence 0.62 Published 2009 Journal J. Comp. Neurol. Section Abstract Doc Link 19235905 Disease Relevance 1.01 Pain Relevance 0.86
CGRP fibers decreased, but GFRalpha1, GFRalpha2 and GFRalpha3 fibers did not change.
Gene_expression (fibers) of GFRalpha3 associated with calcitonin gene-related peptide
17) Confidence 0.62 Published 2009 Journal J. Comp. Neurol. Section Abstract Doc Link 19235905 Disease Relevance 1.00 Pain Relevance 0.86
In order to address the role of GDNF and GFRalpha-1 in neuropathic pain, antisense oligodeoxynucleotide (ODN) specifically against GFRalpha-1 was intrathecally administered to result in down-regulation of GFRalpha-1 expression.
Gene_expression (expression) of GFRalpha-1 associated with neuropathic pain
18) Confidence 0.60 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.32 Pain Relevance 0.94
Down-regulation of GFRalpha-1 expression by antisense oligodeoxynucleotide aggravates thermal hyperalgesia in a rat model of neuropathic pain.
Gene_expression (expression) of GFRalpha-1 associated with neuralgia, thermal hyperalgesia and neuropathic pain
19) Confidence 0.60 Published 2006 Journal Neuropharmacology Section Title Doc Link 16289634 Disease Relevance 1.22 Pain Relevance 1.06
In addition, we found a down-regulation of somatostatin (SOM) in DRG and spinal dorsal horn after expression of GFRalpha-1 was knocked down, which suggested the possible relationship between the anti-hyperalgesic effect of GDNF and GFRalpha-1 on neuropathic pain and endogenous SOM.
Gene_expression (expression) of GFRalpha-1 in dorsal horn associated with ganglion cysts, hyperalgesia, spinal dorsal horn, neuropathic pain and somatostatin
20) Confidence 0.60 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.41 Pain Relevance 1.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox