INT20586

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1983
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 9.43
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra1)
Anatomy Link Frequency
brain 2
hippocampus 2
urine 2
plasma 1
blood 1
Gfra1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 10 99.84 Very High Very High Very High
anesthesia 7 99.66 Very High Very High Very High
fluoxetine 4 99.52 Very High Very High Very High
narcan 3 99.44 Very High Very High Very High
Desipramine 4 99.22 Very High Very High Very High
dopamine receptor 1 98.72 Very High Very High Very High
antidepressant 8 98.30 Very High Very High Very High
Inflammation 18 98.28 Very High Very High Very High
Hippocampus 8 97.56 Very High Very High Very High
antagonist 3 96.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pneumoperitoneum 8 100.00 Very High Very High Very High
Diabetes Mellitus 29 99.84 Very High Very High Very High
Pressure And Volume Under Development 2 99.82 Very High Very High Very High
Convulsion 44 98.36 Very High Very High Very High
INFLAMMATION 43 98.28 Very High Very High Very High
Renal Disease 8 97.72 Very High Very High Very High
Hypertension 4 95.44 Very High Very High Very High
Disorders Of Creatine Metabolism 6 94.24 High High
Apoptosis 71 92.92 High High
Brain Tumor 3 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic (14 days) administration of different classes of antidepressant drugs, including tranylcypromine, desipramine, or fluoxetine, did not significantly affect the GDNF, GFRalpha-1, GFRalpha-2, or RET mRNA levels in CA1, CA3, and dentate gyrus areas of hippocampus.
Neg (not) Regulation (affect) of GFRalpha-2 in hippocampus associated with desipramine, antidepressant, hippocampus and fluoxetine
1) Confidence 0.51 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.82 Pain Relevance 0.30
Regulation of GFRalpha-1 and GFRalpha-2 mRNAs in rat brain by electroconvulsive seizure.
Regulation (Regulation) of GFRalpha-1 in brain associated with convulsion
2) Confidence 0.51 Published 2001 Journal Synapse Section Title Doc Link 11071708 Disease Relevance 0.70 Pain Relevance 0.12
Regulation of GFRalpha-1 and GFRalpha-2 mRNAs in rat brain by electroconvulsive seizure.
Regulation (Regulation) of GFRalpha-2 in brain associated with convulsion
3) Confidence 0.51 Published 2001 Journal Synapse Section Title Doc Link 11071708 Disease Relevance 0.71 Pain Relevance 0.12
Chronic (14 days) administration of different classes of antidepressant drugs, including tranylcypromine, desipramine, or fluoxetine, did not significantly affect the GDNF, GFRalpha-1, GFRalpha-2, or RET mRNA levels in CA1, CA3, and dentate gyrus areas of hippocampus.
Neg (not) Regulation (affect) of GFRalpha-1 in hippocampus associated with desipramine, antidepressant, hippocampus and fluoxetine
4) Confidence 0.51 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.82 Pain Relevance 0.30
We found the simultaneous up-regulation of both co-receptor genes for the neurotrophic factor GDNF (Gfra1 and Ret).
Regulation (regulation) of Gfra1
5) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.81 Pain Relevance 0.05
In fluid loading group, ERPF, UFR and CMBF could maintain throughout the experiment but only GFR was affected in the first 30 min.
Regulation (affected) of GFR
6) Confidence 0.24 Published 2003 Journal Acta Anaesthesiol. Sin. Section Body Doc Link 12747341 Disease Relevance 0 Pain Relevance 0
Further studies in Inactin anaesthetized rats showed that the fall in GFR was unaltered by renal denervation, bilateral adrenalectomy or intrarenal administration of the alpha 1-adrenoceptor antagonist prazosin.
Regulation (unaltered) of GFR associated with antagonist
7) Confidence 0.24 Published 1998 Journal Acta Physiol. Scand. Section Abstract Doc Link 9715736 Disease Relevance 0.68 Pain Relevance 0.21
Such GFR alterations were sought in intact, low NaCl, prehypertensive Dahl S rats.
Regulation (alterations) of GFR
8) Confidence 0.23 Published 1989 Journal Am. J. Hypertens. Section Abstract Doc Link 2757812 Disease Relevance 0.19 Pain Relevance 0.08
Defective autoregulation of GFR has been demonstrated in patients with diabetic and non-diabetic nephropathy and in streptozotocin diabetic rats during hyperglycaemia.
Regulation (autoregulation) of GFR associated with diabetes mellitus and renal disease
9) Confidence 0.20 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11300610 Disease Relevance 0.57 Pain Relevance 0
Therefore the aim of our study was to evaluate the effect of acute lowering of blood pressure (BP) on GFR during normoglycaemia and hyperglycaemia.
Regulation (effect) of GFR in blood
10) Confidence 0.20 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11300610 Disease Relevance 0.62 Pain Relevance 0.19
CONCLUSION: Our study suggests that acute changes in glycaemic control have no detectable effect on autoregulation of GFR in NIDDM patients.
Regulation (autoregulation) of GFR associated with diabetes mellitus
11) Confidence 0.20 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11300610 Disease Relevance 0.29 Pain Relevance 0.21
Information on the potential impact of acute changes in glycaemic control on autoregulation of GFR in diabetic patients is lacking.
Regulation (autoregulation) of GFR associated with diabetes mellitus
12) Confidence 0.20 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11300610 Disease Relevance 0.62 Pain Relevance 0.12
An increase in urine production was the dominant effect (up to 200% of the initial value), with the alterations of GFR and RPF being of minor significance except in one patient with a GFR reduction up to almost 50% the original value.
Regulation (alterations) of GFR in urine
13) Confidence 0.18 Published 1997 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 9442480 Disease Relevance 0.23 Pain Relevance 0.07
We found the simultaneous down-regulation of three out of the four receptors of the GDNF family (Gfra1, Gfra2, Gfra3), as well as the down regulation of Ntrk1 (TrkA) and the Adcyap1r1 receptor.
Regulation (regulation) of Gfra1
14) Confidence 0.14 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.36 Pain Relevance 0.15
They speculated that this difference may be secondary to the effect of prolonged pneumoperitoneum on the GFR.
Regulation (effect) of GFR associated with pneumoperitoneum
15) Confidence 0.11 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2858855 Disease Relevance 0.46 Pain Relevance 0.05
Acute anti-inflammatory doses of flosulide and indomethacin were determined on carrageenan paw edema and its effects on renal plasma flow (RPF) and glomerular filtration rate (GFR) were studied in normovolemic and hypovolemic rats.
Regulation (effects) of GFR in plasma associated with pressure and volume under development and inflammation
16) Confidence 0.10 Published 2001 Journal Inflammation Section Abstract Doc Link 11321358 Disease Relevance 0.45 Pain Relevance 0.18
In rats receiving a continuous infusion of the opiate-receptor antagonist naloxone (0.3 mg . kg-1 . h-1) neither AUN nor UUO produced significant alterations in U Na V or U K V by the CK; naloxone infusion by itself did not alter GFR or basal rates of cation excretion.
Neg (not) Regulation (alter) of GFR associated with antagonist, narcan and opiate
17) Confidence 0.09 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6837737 Disease Relevance 0 Pain Relevance 0.64
After three weeks of treatment, acute study of renal function during pentobarbital anesthesia revealed higher values of GFR and RPF and lowered vascular resistance for nonclipped kidneys from the losartan and enalapril groups compared to the corresponding kidneys from control animals.
Regulation (values) of GFR associated with anesthesia
18) Confidence 0.06 Published 1995 Journal Kidney Int. Section Abstract Doc Link 7637269 Disease Relevance 0.07 Pain Relevance 0.14
A subpressor dose of dopamine had no effect on GFR during the postischemic period (0.25 +/- 0.11 ml/min/100 g).
Neg (no) Regulation (effect) of GFR associated with dopamine
19) Confidence 0.02 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2148187 Disease Relevance 0.42 Pain Relevance 0.28
Calcium channel blockers, such as diltiazem42 and verapamil,43 have been shown to increase urine output and to maintain tubular integrity after cardiac surgery, without significantly affecting the GFR.
Neg (without) Regulation (affecting) of GFR in urine associated with calcium channel
20) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697583 Disease Relevance 0.61 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox