INT205868

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.10
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cerebrospinal fluid 1
brain 1
G4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 16 51.32 Quite High
Bioavailability 5 32.40 Quite Low
Neurotransmitter 12 6.92 Low Low
cytokine 24 5.00 Very Low Very Low Very Low
Pyramidal cell 12 5.00 Very Low Very Low Very Low
Bile 8 5.00 Very Low Very Low Very Low
iatrogenic 6 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 38 99.12 Very High Very High Very High
Contagious Ecthyma 15 88.44 High High
Lymphatic System Cancer 21 82.00 Quite High
Infection 78 71.84 Quite High
Hepatic Encephalopathy 34 70.92 Quite High
Leukemia 45 63.60 Quite High
Disease 57 63.12 Quite High
Hyperammonemia 8 60.00 Quite High
Liver Failure 20 59.84 Quite High
Dementia 2 51.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the excessive levels of the cholinergic G4 AChE in the brain of cirrhotic subjects may have direct physiological consequences causing a decrease of extracellular ACh levels in the brain.
Gene_expression (levels) of G4 in brain associated with cirrhosis
1) Confidence 0.42 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.21 Pain Relevance 0
The decrease of serum G4 levels in BDL rats correlates with a decrease of the tetrameric species in the cerebrospinal fluid (unpublished observation).
Gene_expression (levels) of G4 in cerebrospinal fluid
2) Confidence 0.36 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.32 Pain Relevance 0.03
These deletants are thus unable to express Tax, although all of them could at least in theory, express G4.
Gene_expression (express) of G4
3) Confidence 0.27 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.23 Pain Relevance 0
Similar conclusions were drawn from HTLV mutant proviruses deleted in the ORFs encoding the p12I and p13II/p30II orthologs of R3 and G4 [240-242].
Gene_expression (encoding) of G4
4) Confidence 0.20 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.28 Pain Relevance 0
The R3 and G4 open reading frames
Gene_expression (The) of G4
5) Confidence 0.09 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.07 Pain Relevance 0

General Comments

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