INT205869

Context Info Confidence 0.24 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.23 Pain Relevance 0

Anatomy Link Frequency nucleus 1 intermediate region 1 G4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 16 5.00 iatrogenic 4 5.00 palliative 2 5.00 Central nervous system 2 5.00 transdermal 2 5.00 Inflammation 2 5.00 Pain 2 5.00 alcohol 2 5.00 Bioavailability 2 5.00 metalloproteinase 2 5.00

Disease Link Frequency Relevance Heat Contagious Ecthyma 10 88.16 Enzootic Bovine Leukosis 26 50.00 Pressure And Volume Under Development 2 48.08 Lymphocytosis 66 5.00 Infection 52 5.00 Cancer 44 5.00 Disease 38 5.00 Apoptosis 36 5.00 Leukemia 30 5.00 Death 20 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, G4, like p13II, is localized both in the nucleus and in mitochondria [169].

Localization (localized) of G4 in nucleus

1) Confidence 0.24 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.15 Pain Relevance 0

The R3 and G4 open reading frames (orfs) belong to an intermediate region located between the envelope and the tax/rex genes.

Localization (located) of G4 in intermediate region

2) Confidence 0.22 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.08 Pain Relevance 0

However, more content of PLGA (85:15) showed the slowest BSA release in G4 among the formulations studied and it might be due to the enhancement of hydrophobicity.

Localization (release) of G4

3) Confidence 0.12 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636584 Disease Relevance 0 Pain Relevance 0

When the cumulative percentages of the protein release from the experimental formulations were plotted against time, it was found that about 84% protein was released in 50 days in case of the formulation G3, whereas, G4 had a release of about 42% in the same time period (Figure 7).

Localization (release) of G4

4) Confidence 0.11 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636584 Disease Relevance 0 Pain Relevance 0

General Comments

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