INT205884

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.72
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mat2b) nucleus (Mat2b)
Anatomy Link Frequency
cerebral cortex 6
Mat2b (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 130 99.84 Very High Very High Very High
Hippocampus 135 90.96 High High
adenocard 5 64.16 Quite High
gABA 70 55.76 Quite High
Glutamate receptor 5 49.28 Quite Low
Neurotransmitter 5 35.00 Quite Low
GABAergic 25 34.32 Quite Low
Thalamus 5 11.92 Low Low
midbrain 5 11.52 Low Low
cytokine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 20 82.52 Quite High
Parkinson's Disease 15 82.16 Quite High
Targeted Disruption 40 74.84 Quite High
Convulsion 15 22.56 Low Low
Cancer 5 10.96 Low Low
INFLAMMATION 25 5.00 Very Low Very Low Very Low
Aging 10 5.00 Very Low Very Low Very Low
Overdose 5 5.00 Very Low Very Low Very Low
Epilepsy 5 5.00 Very Low Very Low Very Low
Decapitation 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because increased levels of S-adenosylmethionine are observed when MAT2B is downregulated [19], we could predict that increased expression of MAT2B, as observed in our study, would result in decreased S-adenosylmethionine, which is the exclusive methyl donor for transmethylation reactions [19-21].
Positive_regulation (increased) of Gene_expression (expression) of MAT2B
1) Confidence 0.59 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.32 Pain Relevance 0.12
Our study demonstrated that the expressions of MAT2B and AHCY mRNA, the protein products of which are two tandem enzymes involved in methionine metabolism, are upregulated in the cerebral cortex of COX-2-/- but not of COX-1-/- mice.
Positive_regulation (upregulated) of Gene_expression (expressions) of MAT2B in cerebral cortex associated with cerebral cortex
2) Confidence 0.42 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.40 Pain Relevance 0.10
Expression of methionine adenosyltransferase II (MAT2B) and adenosylhomocysteine hydrolase (AHCY), two genes that work in tandem to metabolize methionine to homocysteine, was increased in cerebral cortex of COX-2-/- mice (Figure 2).
Positive_regulation (increased) of Gene_expression (Expression) of MAT2B in cerebral cortex associated with cerebral cortex
3) Confidence 0.42 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.23
Expression of methionine adenosyltransferase II (MAT2B) and adenosylhomocysteine hydrolase (AHCY), two genes that work in tandem to metabolize methionine to homocysteine, was increased in cerebral cortex of COX-2-/- mice (Figure 2).
Positive_regulation (increased) of Gene_expression (Expression) of methionine adenosyltransferase II in cerebral cortex associated with cerebral cortex
4) Confidence 0.42 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.23
MAT2B expression was found to be increased in microarray analysis (z ratio = +2.79) and by Q-PCR analysis (138% ± 12% in COX-2-/- mice versus 100% ± 25% in wild-type mice; t statistic = -3.14, P = 0.013).
Positive_regulation (increased) of Gene_expression (expression) of MAT2B
5) Confidence 0.39 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.22

General Comments

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