INT205888

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 8.00
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) Golgi apparatus (Pla2g4a) endoplasmic reticulum (Pla2g4a)
nucleus (Pla2g4a) cytoplasm (Pla2g4a)
Anatomy Link Frequency
brain 2
epithelial cells 2
bowel 2
Pla2g4a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 35 99.02 Very High Very High Very High
Hippocampus 81 91.12 High High
Inflammation 78 84.56 Quite High
agonist 6 81.12 Quite High
gABA 42 76.08 Quite High
Inflammatory stimuli 2 74.80 Quite High
cerebral cortex 78 65.48 Quite High
Analgesic 9 64.88 Quite High
rheumatoid arthritis 3 60.32 Quite High
aspirin 16 59.52 Quite High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 6 99.96 Very High Very High Very High
Adenoma 30 99.36 Very High Very High Very High
Cystic Fibrosis 35 99.02 Very High Very High Very High
Colon Cancer 222 98.88 Very High Very High Very High
Adenocarcinoma 6 97.68 Very High Very High Very High
Cancer 292 97.40 Very High Very High Very High
Targeted Disruption 39 94.24 High High
Recurrence 30 93.20 High High
Polyps 7 88.88 High High
Disease 25 87.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is in agreement with previous studies reporting that epithelial cells from CF patients release more AA than control cells and express higher levels of cPLA2?
Positive_regulation (levels) of Gene_expression (express) of cPLA2 in epithelial cells associated with fibrosis
1) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.19 Pain Relevance 0.12
In conclusion, the present study demonstrates that cPLA2 and mPGES-1, in addition to COX-2, are constitutively overexpressed, and that 15-PGDH might be attenuated in colorectal carcinoma.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cPLA2 associated with colon cancer
2) Confidence 0.59 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.07 Pain Relevance 0
Some have suggested that cPLA2 is overexpressed,38-40 whereas others have concluded to the contrary.36,41,42 However, the study sample sizes were relatively small, i.e., ranging from 5 to 48.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cPLA2
3) Confidence 0.59 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.32 Pain Relevance 0
Panel, et al.27 reported that cPLA2 was overexpressed in 49% of 65 patients with colorectal cancers, and that cPLA2 expression was correlated with COX-2 expression, which concurs with our findings; i.e., we demonstrated that cPLA2 was overexpressed in 54.5% of CRCs (n = 88), and that cPLA2 expression was correlated with the expressions of COX-2 and VEGF.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cPLA2 associated with colon cancer
4) Confidence 0.59 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.25 Pain Relevance 0
Panel, et al.27 reported that cPLA2 was overexpressed in 49% of 65 patients with colorectal cancers, and that cPLA2 expression was correlated with COX-2 expression, which concurs with our findings; i.e., we demonstrated that cPLA2 was overexpressed in 54.5% of CRCs (n = 88), and that cPLA2 expression was correlated with the expressions of COX-2 and VEGF.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cPLA2 associated with colon cancer
5) Confidence 0.59 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.29 Pain Relevance 0
In two animal models of familial adenomatous polyposis, cPLA2 was overexpressed in small bowel adenoma, but not in colonic adenoma.
Neg (not) Positive_regulation (overexpressed) of Neg (not) Gene_expression (overexpressed) of cPLA2 in bowel associated with adenoma and familial adenomatous polyposis
6) Confidence 0.59 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.48 Pain Relevance 0
Seventy nine of total 89 cases were evaluated for both COX-2 expression and cPLA2 expression.
Positive_regulation (evaluated) of Gene_expression (expression) of cPLA2
7) Confidence 0.43 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.56 Pain Relevance 0
Upregulation of gene expression of cPLA2, which releases AA from phospholipids, as previously described by Q-PCR in whole brain of COX-1-/- and COX-2-/- mice [5,6], was not detected in cortex (COX-1: z ratio = 0.72, P = 0.03; COX-2: z ratio = 0.04, P = 0.9) and hippocampus (COX-1: z ratio = -0.89, P = 0.002; COX-2: z ratio = 0.60, P = 0.13) by microarray analysis.
Positive_regulation (Upregulation) of Gene_expression (expression) of cPLA2 in brain associated with hippocampus
8) Confidence 0.32 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.27
Similar alterations have been observed in COX-1-/- mice, in which COX-2 protein expression and cPLA2 and secretory phospholipase A2 gene and protein expression are increased [6].
Positive_regulation (increased) of Gene_expression (expression) of cPLA2
9) Confidence 0.32 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.07 Pain Relevance 0.10
Similar alterations have been observed in COX-1-/- mice, in which COX-2 protein expression and cPLA2 and secretory phospholipase A2 gene and protein expression are increased [6].
Positive_regulation (increased) of Gene_expression (expression) of cPLA2
10) Confidence 0.32 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.07 Pain Relevance 0.10
Up to date, three PGE synthases have been described: The microsomal and inducible mPGES-1, the constitutively expressed cytosolic cPGES and the most recently discovered microsomal mPGES-2 [25-29].
Positive_regulation (inducible) of Gene_expression (expressed) of cytosolic
11) Confidence 0.06 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.70 Pain Relevance 0.23
The first cytosolic PLA2 discovered was PLA2G4A and it has received, by far, the most attention.
Positive_regulation (discovered) of Gene_expression (discovered) of cytosolic PLA2
12) Confidence 0.03 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0 Pain Relevance 0.08

General Comments

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