INT205889
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Because increased levels of S-adenosylmethionine are observed when MAT2B is downregulated [19], we could predict that increased expression of MAT2B, as observed in our study, would result in decreased S-adenosylmethionine, which is the exclusive methyl donor for transmethylation reactions [19-21]. | |||||||||||||||
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Expression of MAT2B, but not of AHCY, was decreased in COX-1-/- hippocampus (z ratio = -3.07; 78% ± 13% in COX-1-/- mice versus 100% ± 18% in wild-type mice; t statistic = 2.39, P = 0.04).
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MAT2B expression was found to be increased in microarray analysis (z ratio = +2.79) and by Q-PCR analysis (138% ± 12% in COX-2-/- mice versus 100% ± 25% in wild-type mice; t statistic = -3.14, P = 0.013). | |||||||||||||||
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Expression of methionine adenosyltransferase II (MAT2B) and adenosylhomocysteine hydrolase (AHCY), two genes that work in tandem to metabolize methionine to homocysteine, was increased in cerebral cortex of COX-2-/- mice (Figure 2). | |||||||||||||||
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Expression of methionine adenosyltransferase II (MAT2B) and adenosylhomocysteine hydrolase (AHCY), two genes that work in tandem to metabolize methionine to homocysteine, was increased in cerebral cortex of COX-2-/- mice (Figure 2). | |||||||||||||||
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Our study demonstrated that the expressions of MAT2B and AHCY mRNA, the protein products of which are two tandem enzymes involved in methionine metabolism, are upregulated in the cerebral cortex of COX-2-/- but not of COX-1-/- mice. | |||||||||||||||
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