INT205889

Context Info Confidence 0.66 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 6 Disease Relevance 0.78 Pain Relevance 1.19

mitochondrion (Mat2b) nucleus (Mat2b)

Anatomy Link Frequency cerebral cortex 3 hippocampus 1 Mat2b (Mus musculus)

Pain Link Frequency Relevance Heat cerebral cortex 156 98.80 Hippocampus 162 98.20 gABA 84 86.32 adenocard 6 64.16 Glutamate receptor 6 49.28 Neurotransmitter 6 35.00 GABAergic 30 34.32 Thalamus 6 11.92 midbrain 6 11.52 cytokine 24 5.00

Disease Link Frequency Relevance Heat Middle Cerebral Artery Infarction 24 82.52 Parkinson's Disease 18 82.16 Targeted Disruption 48 74.84 Convulsion 18 22.56 Cancer 6 10.96 INFLAMMATION 30 5.00 Aging 12 5.00 Overdose 6 5.00 Epilepsy 6 5.00 Decapitation 6 5.00

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because increased levels of S-adenosylmethionine are observed when MAT2B is downregulated [19], we could predict that increased expression of MAT2B, as observed in our study, would result in decreased S-adenosylmethionine, which is the exclusive methyl donor for transmethylation reactions [19-21].

Gene_expression (expression) of MAT2B

1) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.32 Pain Relevance 0.12

Expression of MAT2B, but not of AHCY, was decreased in COX-1-/- hippocampus (z ratio = -3.07; 78% ± 13% in COX-1-/- mice versus 100% ± 18% in wild-type mice; t statistic = 2.39, P = 0.04).

Gene_expression (Expression) of MAT2B in hippocampus associated with hippocampus

2) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.07 Pain Relevance 0.37

MAT2B expression was found to be increased in microarray analysis (z ratio = +2.79) and by Q-PCR analysis (138% ± 12% in COX-2-/- mice versus 100% ± 25% in wild-type mice; t statistic = -3.14, P = 0.013).

Gene_expression (expression) of MAT2B

3) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.21

Expression of methionine adenosyltransferase II (MAT2B) and adenosylhomocysteine hydrolase (AHCY), two genes that work in tandem to metabolize methionine to homocysteine, was increased in cerebral cortex of COX-2-/- mice (Figure 2).

Gene_expression (Expression) of MAT2B in cerebral cortex associated with cerebral cortex

4) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.20

Expression of methionine adenosyltransferase II (MAT2B) and adenosylhomocysteine hydrolase (AHCY), two genes that work in tandem to metabolize methionine to homocysteine, was increased in cerebral cortex of COX-2-/- mice (Figure 2).

Gene_expression (Expression) of methionine adenosyltransferase II in cerebral cortex associated with cerebral cortex

5) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.20

Our study demonstrated that the expressions of MAT2B and AHCY mRNA, the protein products of which are two tandem enzymes involved in methionine metabolism, are upregulated in the cerebral cortex of COX-2-/- but not of COX-1-/- mice.

Gene_expression (expressions) of MAT2B in cerebral cortex associated with cerebral cortex

6) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.40 Pain Relevance 0.10

General Comments

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