INT205893

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 17
Disease Relevance 7.01
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ahcy) nucleus (Ahcy)
Anatomy Link Frequency
brain 5
cerebral cortex 3
neuronal 1
cortex 1
hippocampus 1
Ahcy (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 27 99.92 Very High Very High Very High
Hippocampus 209 98.88 Very High Very High Very High
cerebral cortex 182 98.00 Very High Very High Very High
Glutamate receptor 7 95.56 Very High Very High Very High
Neurotransmitter 17 94.20 High High
gABA 98 87.68 High High
GABAergic 35 51.52 Quite High
GABA receptor 14 28.64 Quite Low
Thalamus 7 11.92 Low Low
midbrain 7 11.52 Low Low
Disease Link Frequency Relevance Heat
Aging 204 99.20 Very High Very High Very High
Disease 380 97.06 Very High Very High Very High
Cognitive Disorder 70 96.84 Very High Very High Very High
Convulsion 21 92.56 High High
Middle Cerebral Artery Infarction 28 82.52 Quite High
Parkinson's Disease 21 82.16 Quite High
Stress 10 80.24 Quite High
Increased Venous Pressure Under Development 20 78.56 Quite High
Targeted Disruption 86 74.96 Quite High
Hyperhomocysteinemia 50 70.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased AHCY expression, as detected by microarray analysis (z ratio= +1.66), was validated by Q-PCR (123% ± 5% in COX-2-/- mice versus 100% ± 14% in wild-type mice; t statistic = -3.76, P = 0.01).
Gene_expression (expression) of AHCY
1) Confidence 0.63 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.06 Pain Relevance 0.33
Our study demonstrated that the expressions of MAT2B and AHCY mRNA, the protein products of which are two tandem enzymes involved in methionine metabolism, are upregulated in the cerebral cortex of COX-2-/- but not of COX-1-/- mice.
Gene_expression (expressions) of AHCY mRNA in cerebral cortex associated with cerebral cortex
2) Confidence 0.63 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.40 Pain Relevance 0.10
Expression of methionine adenosyltransferase II (MAT2B) and adenosylhomocysteine hydrolase (AHCY), two genes that work in tandem to metabolize methionine to homocysteine, was increased in cerebral cortex of COX-2-/- mice (Figure 2).
Gene_expression (Expression) of adenosylhomocysteine hydrolase in cerebral cortex associated with cerebral cortex
3) Confidence 0.63 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.22
Expression of methionine adenosyltransferase II (MAT2B) and adenosylhomocysteine hydrolase (AHCY), two genes that work in tandem to metabolize methionine to homocysteine, was increased in cerebral cortex of COX-2-/- mice (Figure 2).
Gene_expression (Expression) of AHCY in cerebral cortex associated with cerebral cortex
4) Confidence 0.63 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.22
Expression of MAT2B, but not of AHCY, was decreased in COX-1-/- hippocampus (z ratio = -3.07; 78% ± 13% in COX-1-/- mice versus 100% ± 18% in wild-type mice; t statistic = 2.39, P = 0.04).


Gene_expression (Expression) of AHCY in hippocampus associated with hippocampus
5) Confidence 0.55 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.07 Pain Relevance 0.40
Increased expression of AHCY in the cortex of COX-2-/- mice is predicted to increase the production of adenosine and homocysteine [23].
Gene_expression (expression) of AHCY in cortex associated with adenocard
6) Confidence 0.55 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.15 Pain Relevance 0.16
The possibility that increased expression of AHCY results in elevated homocysteine concentrations is consistent with a preliminary observation made in our laboratory indicating that COX-2-/- mice, but not COX-1-/- mice, have increased seizure intensity and neuronal damage after systemic injection with kainic acid [26].
Gene_expression (expression) of AHCY in neuronal associated with convulsion
7) Confidence 0.55 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.16 Pain Relevance 0.20
However, it is important to mention that this hydrolysis is a reversible reaction that favors the synthesis of AdoHcy.
Gene_expression (synthesis) of AdoHcy
8) Confidence 0.17 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.75 Pain Relevance 0.14
Subsequently, AdoHcy can be hydrolyzed to Hcy and adenosine by AdoHcy hydrolase.
Gene_expression (hydrolase) of AdoHcy associated with adenocard
9) Confidence 0.14 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.83 Pain Relevance 0.14
AdoMet and AdoHcy might also influence AD like pathology and vascular health [16] and it could be hypothesized that the above-mentioned nutritional components may influence and AdoMet and AdoHcy levels as well.


Gene_expression (levels) of AdoHcy associated with disease
10) Confidence 0.13 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.72 Pain Relevance 0.03
However, because of a lack of brain tissue we only measured AdoMet and AdoHcy levels in this experiment.
Gene_expression (levels) of AdoHcy in brain
11) Confidence 0.13 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.53 Pain Relevance 0
This is the first study describing AdoMet and AdoHcy levels in brain tissue of aging mice.
Gene_expression (levels) of AdoHcy in brain associated with aging
12) Confidence 0.13 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.60 Pain Relevance 0
In addition, high Hcy levels are known to inhibit AdoHcy hydrolase, which results in increase in AdoHcy levels [32], and therefore higher AdoHcy levels would have been expected in our APP/PS1 mice compared to wild types which was also not the case.
Gene_expression (levels) of AdoHcy
13) Confidence 0.13 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.44 Pain Relevance 0
In addition, high Hcy levels are known to inhibit AdoHcy hydrolase, which results in increase in AdoHcy levels [32], and therefore higher AdoHcy levels would have been expected in our APP/PS1 mice compared to wild types which was also not the case.
Gene_expression (levels) of AdoHcy
14) Confidence 0.13 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.44 Pain Relevance 0
In addition, we showed that cholesterol-containing, or DHA-enriched diets did not affect AdoMet or AdoHcy levels in brain tissue of APP/PS1 and wild-type mice.
Gene_expression (levels) of AdoHcy in brain
15) Confidence 0.11 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.59 Pain Relevance 0
The finding that cholesterol- or DHA-containing diets do not alter AdoMet or AdoHcy levels in brain tissue of either wild type or APP/PS1 mice, but in contrast do have effects on AD pathology and cerebral hemodynamics [7, 15, 29], suggests that cholesterol- or DHA-containing diets do not influence cerebral hemodynamics or AD pathology via the methylation cycle.
Gene_expression (levels) of AdoHcy in brain associated with disease
16) Confidence 0.11 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.64 Pain Relevance 0
Neither a cholesterol- nor a DHA-containing diet did alter AdoMet or AdoHcy levels in brain tissue of 8- and 15-month-old APP/PS1 and wild-type mice as compared to the standard diet (data not shown).


Gene_expression (levels) of AdoHcy in brain
17) Confidence 0.11 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.63 Pain Relevance 0

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