INT2059

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2009
Negated 4
Speculated 2
Reported most in Abstract
Documents 24
Total Number 26
Disease Relevance 5.70
Pain Relevance 9.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 8
pituitary 6
face 4
anterior pituitary 3
brain 2
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 17 100.00 Very High Very High Very High
dexamethasone 8 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
noradrenaline 2 100.00 Very High Very High Very High
Sumatriptan 4 99.98 Very High Very High Very High
narcan 27 99.84 Very High Very High Very High
Endogenous opioid 6 99.84 Very High Very High Very High
Dopamine 15 99.78 Very High Very High Very High
antagonist 26 99.76 Very High Very High Very High
dopamine receptor 1 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 22 100.00 Very High Very High Very High
Convulsion 8 100.00 Very High Very High Very High
Eating Disorder 7 98.72 Very High Very High Very High
Headache 6 98.48 Very High Very High Very High
Diabetes Mellitus 10 98.12 Very High Very High Very High
Aging 4 98.04 Very High Very High Very High
Galactorrhea 10 97.72 Very High Very High Very High
Epilepsy 1 97.12 Very High Very High Very High
Reprotox - General 1 4 96.72 Very High Very High Very High
Endocrine Disease 1 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A decrease of plasma PRL levels was also induced by IDZ but not by YOH, which tended further to increase hyperprolactinemia.
Neg (not) Positive_regulation (induced) of Negative_regulation (decrease) of PRL in plasma associated with galactorrhea
1) Confidence 0.70 Published 1991 Journal Horm. Metab. Res. Section Abstract Doc Link 1678730 Disease Relevance 0.34 Pain Relevance 0.51
Contrarily, in rats anesthetized with pentobarbital, acetylcholine at the same doses induced significant decreases of prolactin from 10 to 60 min postinjection.
Positive_regulation (induced) of Negative_regulation (decreases) of prolactin
2) Confidence 0.69 Published 1975 Journal J. Neural Transm. Section Abstract Doc Link 1206392 Disease Relevance 0 Pain Relevance 0.13
This result suggested that an increase in dopamine secretion mediated the stress-induced decrease of PRL in the afternoon.
Positive_regulation (mediated) of Negative_regulation (decrease) of PRL associated with stress and dopamine
3) Confidence 0.50 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3724981 Disease Relevance 0.34 Pain Relevance 0.76
These findings suggest that during the aging process not only quantitative changes but also qualitative changes occur in PRL secretion, which result in an overall decline in the biopotency of PRL released into the circulation.
Positive_regulation (result) of Negative_regulation (decline) of PRL associated with aging
4) Confidence 0.50 Published 1990 Journal Endocrinology Section Abstract Doc Link 2105206 Disease Relevance 0.10 Pain Relevance 0.06
The gradual increase in prolactin levels in the third week of life is not related to a decrease in dopaminergic inhibition but to an increase in the efficiency of prolactin releasing factors such as estrogen, serotonin, opiates, and posterior pituitary extracts. 4.
Positive_regulation (increase) of Negative_regulation (efficiency) of prolactin in posterior pituitary associated with opiate and serotonin
5) Confidence 0.50 Published 1992 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 1571952 Disease Relevance 0.09 Pain Relevance 0.15
Face cooling-induced reduction of plasma prolactin response to exercise as part of an integrated response to thermal stress.
Positive_regulation (cooling-induced) of Negative_regulation (reduction) of prolactin in Face associated with stress
6) Confidence 0.50 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Title Doc Link 2527748 Disease Relevance 0.25 Pain Relevance 0
A reduction in nursing frequency seems likely to lead to reduced prolactin levels and altered patterns of somatotropin secretion.
Spec (likely) Positive_regulation (lead) of Negative_regulation (reduced) of prolactin
7) Confidence 0.49 Published 1993 Journal Physiol. Behav. Section Abstract Doc Link 8383345 Disease Relevance 0.15 Pain Relevance 0.46
To examine the hypothesis that the increased adrenocortical activity during lactation induced the loss of the prolactin (PRL) -releasing effect of morphine, we studied the effect of morphine in adrenalectomized (ADX) and sham-operated primiparous lactating Wistar rats.
Spec (examine) Positive_regulation (induced) of Negative_regulation (loss) of PRL associated with morphine
8) Confidence 0.47 Published 1991 Journal Brain Res. Section Abstract Doc Link 1786530 Disease Relevance 0.05 Pain Relevance 0.47
Naloxone administration did not decrease previously increased mean serum levels of prolactin in pituitary-grafted rats.
Positive_regulation (increased) of Neg (not) Negative_regulation (decrease) of prolactin in pituitary associated with narcan
9) Confidence 0.47 Published 1994 Journal Vet Hum Toxicol Section Abstract Doc Link 7900271 Disease Relevance 0.07 Pain Relevance 0.72
These changes are suggested to be responsible for the significant reduction in serum prolactin (PRL) response to a brief restraint stress in diabetic male rats, as compared with normoglycemic controls.
Positive_regulation (responsible) of Negative_regulation (reduction) of prolactin associated with stress and diabetes mellitus
10) Confidence 0.47 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8171046 Disease Relevance 0.61 Pain Relevance 0.40
Cysteamine induces depletion of both immunological and biological prolactin activity in the anterior pituitary and blood of the rat.
Positive_regulation (induces) of Negative_regulation (depletion) of prolactin in anterior pituitary
11) Confidence 0.47 Published 1983 Journal Endocrinology Section Title Doc Link 6641630 Disease Relevance 0 Pain Relevance 0.21
This study was designed to verify if the decrease in blood prolactin (PRL) induced by selective face cooling during exercise could be part of a response to specific body thermal stress.
Positive_regulation (induced) of Negative_regulation (decrease) of PRL in face associated with stress
12) Confidence 0.47 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2527748 Disease Relevance 0.17 Pain Relevance 0
Icv administration of the hexapeptide homologue (dermorphin 1-6 amide) to OVX rats did not induce any PRL rise or LH inhibition, even at the high dose of 250 pmol/100g.
Neg (not) Positive_regulation (induce) of Negative_regulation (inhibition) of PRL
13) Confidence 0.46 Published 1985 Journal Life Sci. Section Abstract Doc Link 3982229 Disease Relevance 0 Pain Relevance 0.20
Finally, we assessed the role of pituitary dopamine receptors on the phenomenon of MS-induced PRL suppression in EB/oil rats.
Positive_regulation (induced) of Negative_regulation (suppression) of PRL in pituitary associated with dopamine receptor
14) Confidence 0.46 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1407373 Disease Relevance 0 Pain Relevance 0.65
It seems that the main reason for "the drying up of milk" is the lack of stimulation of the nipples, which after a releatively constant time of 5--10 days will lead to decreased prolactin levels.
Positive_regulation (lead) of Negative_regulation (decreased) of prolactin in nipples
15) Confidence 0.45 Published 1977 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 327749 Disease Relevance 0 Pain Relevance 0.09
Different clinical investigations and double blind trials have shown that preparations containing Vitex agnus castus fruit extract are a useful tool to decrease pathophysiologicaly increased prolactin serum levels and though could be an effective treatment for women suffering from premenstrual syndrome.
Positive_regulation (increased) of Negative_regulation (decrease) of prolactin associated with dismenorea
16) Confidence 0.45 Published 2009 Journal Med Monatsschr Pharm Section Abstract Doc Link 19469189 Disease Relevance 0.83 Pain Relevance 0.45
Cysteamine is formed by degradation of coenzyme A (CoA) and causes somatostatin (SS), prolactin and noradrenaline depletion in the brain and peripheral tissues. 2.
Positive_regulation (causes) of Negative_regulation (depletion) of prolactin in brain associated with noradrenaline and somatostatin
17) Confidence 0.45 Published 1990 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 2277850 Disease Relevance 0.47 Pain Relevance 0.45
Bicuculline (a GABAergic antagonist) had no effect while phentolamine (an alpha-adrenergic antagonist) and phenoxybenzamine (an alpha-adrenergic antagonist) initially increased and then decreased plasma PRL.
Neg (no) Positive_regulation (increased) of Negative_regulation (decreased) of plasma PRL in plasma associated with antagonist and gabaergic
18) Confidence 0.41 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3724981 Disease Relevance 0.28 Pain Relevance 0.93
Treatment with 10 mg/kg bromocryptine resulted in significantly greater decreases in plasma irPRL levels in young rats, but induced similar decreases in bioPRL levels in both age groups.
Positive_regulation (induced) of Negative_regulation (decreases) of bioPRL in plasma
19) Confidence 0.41 Published 1990 Journal Endocrinology Section Abstract Doc Link 2105206 Disease Relevance 0.20 Pain Relevance 0.08
The maximum decline in serum prolactin level was reached at 720 min after administration.
Positive_regulation (reached) of Negative_regulation (decline) of serum prolactin
20) Confidence 0.40 Published 1996 Journal Gynecol. Endocrinol. Section Abstract Doc Link 9032565 Disease Relevance 0.34 Pain Relevance 0.07

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