INT205904

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.58
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hsd17b10) oxidoreductase activity (Hsd17b10) endoplasmic reticulum (Hsd17b10)
Anatomy Link Frequency
cerebral cortex 2
nervous system 2
brain 1
hippocampus 1
Hsd17b10 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 198 98.24 Very High Very High Very High
cerebral cortex 183 98.12 Very High Very High Very High
antidepressant 90 80.08 Quite High
Neurotransmitter 11 79.56 Quite High
GABAergic 35 78.88 Quite High
Central nervous system 2 69.48 Quite High
Eae 6 57.32 Quite High
Thalamus 7 56.48 Quite High
midbrain 7 56.08 Quite High
depression 56 31.36 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 38 100.00 Very High Very High Very High
Targeted Disruption 66 99.88 Very High Very High Very High
Middle Cerebral Artery Infarction 28 97.44 Very High Very High Very High
Parkinson's Disease 21 97.08 Very High Very High Very High
Cognitive Disorder 20 92.96 High High
Apoptosis 1 90.80 High High
Cancer 7 89.44 High High
Dementia 11 88.76 High High
Neuroblastoma 3 86.40 High High
Disease 97 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Q-PCR also demonstrated an increase in HADH2 expression (143% ± 24% in COX-2-/- mice versus 100% ± 20% in wild-type mice; t statistic = -3.26, P = 0.01).
Gene_expression (expression) of HADH2
1) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.32
It is unclear whether increased expression of HADH2 in COX-2-/- mice, as observed in the present study, contributed to those previous findings, but it is interesting that mice overexpressing HADH2 and COX-2-/- mice are both resistant to the aforementioned nervous system insults.


Gene_expression (overexpressing) of HADH2 in nervous system
2) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.44 Pain Relevance 0.08
Gene expression of ACAT 1, but not that of HADH2 and ACLY, was found to be decreased in the hippocampus of COX-1-/- mice (z ratio= -3.00; 72% ± 6% in COX-1-/- mice versus 100% ± 21% in wild-type mice; t statistic = 2.99, P = 0.03).


Gene_expression (expression) of HADH2 in hippocampus associated with hippocampus
3) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.23
Transgenic mice overexpressing HADH2 have proved to be more resistant to the brain damage associated with MCAO and MPTP [8,9].
Gene_expression (overexpressing) of HADH2 in brain associated with parkinson's disease, targeted disruption and middle cerebral artery infarction
4) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.47 Pain Relevance 0.03
Our findings demonstrate that expressions of HADH2, ACAT1, and ACLY mRNA were upregulated in the cerebral cortex of COX-2-/- mice.
Gene_expression (expressions) of HADH2 in cerebral cortex associated with cerebral cortex
5) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.09 Pain Relevance 0.10
It is unclear whether increased expression of HADH2 in COX-2-/- mice, as observed in the present study, contributed to those previous findings, but it is interesting that mice overexpressing HADH2 and COX-2-/- mice are both resistant to the aforementioned nervous system insults.


Gene_expression (expression) of HADH2 in nervous system
6) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.47 Pain Relevance 0.07
Expression of HADH2 was determined to be increased in microarray analysis of cerebral cortex of COX-2-/- mice with a z ratio of +1.60.
Gene_expression (Expression) of HADH2 in cerebral cortex associated with cerebral cortex
7) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.39
In preclinical studies, Ginkgo biloba extract (EGB 761) blocked the production of amyloid beta peptide and amyloid precursor protein in aged rodents [191].
Gene_expression (production) of amyloid beta peptide associated with alzheimer's dementia
8) Confidence 0.01 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 1.10 Pain Relevance 0.23

General Comments

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