INT205910

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Jak2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 98.90 Very High Very High Very High
Hippocampus 27 93.12 High High
Inflammation 4 80.88 Quite High
cytokine 4 79.72 Quite High
GABAergic 5 63.00 Quite High
Neuronal excitability 1 52.24 Quite High
gABA 14 46.08 Quite Low
cerebral cortex 26 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
GABA receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 93.04 High High
INFLAMMATION 5 80.88 Quite High
Convulsion 3 32.24 Quite Low
Middle Cerebral Artery Infarction 4 5.00 Very Low Very Low Very Low
Parkinson's Disease 3 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although this is the first report to demonstrate a JAK alteration in COX-/- mice, COX-2 inhibitors have been shown to dampen interleukin-12 signaling by inhibiting the activation of JAK2 [38].
Negative_regulation (inhibiting) of Positive_regulation (activation) of JAK2 associated with cox-2 inhibitor
1) Confidence 0.33 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.26 Pain Relevance 0.35

General Comments

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