INT205912

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.10
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Anatomy Link Frequency
hippocampus 2
Jak2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 54 100.00 Very High Very High Very High
cytokine 20 92.36 High High
COX-2 inhibitor 3 90.40 High High
metalloproteinase 3 86.72 High High
cerebral cortex 52 77.20 Quite High
GABAergic 10 75.64 Quite High
palliative 6 70.28 Quite High
Neuronal excitability 2 64.88 Quite High
Inflammation 17 62.96 Quite High
gABA 28 58.72 Quite High
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 39 99.92 Very High Very High Very High
Myelodysplastic Syndromes 101 99.30 Very High Very High Very High
Hematological Disease 25 98.92 Very High Very High Very High
Hepatocellular Cancer 234 97.80 Very High Very High Very High
Apoptosis 112 97.08 Very High Very High Very High
Targeted Disruption 37 94.48 High High
Liver Cancer 6 81.68 Quite High
Myeloid Leukemia 20 79.80 Quite High
Cancer 247 75.20 Quite High
Adhesions 2 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2a in 27 PV patients, Kiladjian et al. show a decrease of JAK2 mutant expression in 24 cases (89%).
Negative_regulation (decrease) of Gene_expression (expression) of JAK2 associated with myelodysplastic syndromes
1) Confidence 0.42 Published 2007 Journal Intern Emerg Med Section Body Doc Link PMC2780604 Disease Relevance 0.81 Pain Relevance 0
Targeting the JAK2V617F mutation and associated signal transduction pathways
Negative_regulation (Targeting) of Gene_expression (mutation) of JAK2V617F
2) Confidence 0.41 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 0.49 Pain Relevance 0.04
On the other hand, JAK-2 expression was decreased in COX-2-/- but not in COX-1-/- mice (z ratio = -2.09).
Negative_regulation (decreased) of Gene_expression (expression) of JAK-2
3) Confidence 0.33 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.28
We found that JAK1 mRNA expression, but not that of JAK2, is increased in the hippocampus of COX-1-/- mice, and that JAK2, but not JAK1, is decreased in the hippocampus of COX-2-/- mice.
Negative_regulation (decreased) of Gene_expression (expression) of JAK2 in hippocampus associated with hippocampus
4) Confidence 0.33 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.23 Pain Relevance 0.44
Microarray analysis revealed reduced expression of Bcl-xL and Jak2 in FL of CIAPIN1 null mice, suggesting that CIAPIN1 might exert its function by upregulating the expression of Bcl-xL and Jak2.
Negative_regulation (reduced) of Gene_expression (expression) of Jak2
5) Confidence 0.27 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.01 Pain Relevance 0.07
Previous microarray analysis revealed that the expressions of Bcl-xL and Jak2 were downregulated in FL of CIAPIN1-null mice (15).
Negative_regulation (downregulated) of Gene_expression (expressions) of Jak2
6) Confidence 0.20 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.29 Pain Relevance 0.03
Microarray analysis revealed reduced expression of Bcl-xL and Jak2 in FL of CIAPIN1 null mice, suggesting that CIAPIN1 might exert its function by upregulating the expression of Bcl-xL and Jak2.
Negative_regulation (revealed) of Gene_expression (expression) of Jak2
7) Confidence 0.20 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.01 Pain Relevance 0.07
Most conspicuous is activation of the Jak/Stat pathway as indicated by elevated expression of Jak2 and Stat1, decreased expression of Socs1 and increased expression of several Stat target genes (Myc, Irf1, Igsf3g and Usp20) (Fig. 11A).
Negative_regulation (decreased) of Gene_expression (expression) of Jak2
8) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.25 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox