INT205918

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.48
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hsd17b10) oxidoreductase activity (Hsd17b10) endoplasmic reticulum (Hsd17b10)
Anatomy Link Frequency
cerebral cortex 4
nervous system 4
brain 2
Hsd17b10 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 156 99.68 Very High Very High Very High
Neurotransmitter 6 79.56 Quite High
GABAergic 30 78.88 Quite High
Hippocampus 162 66.88 Quite High
Thalamus 6 56.48 Quite High
midbrain 6 56.08 Quite High
adenocard 6 13.28 Low Low
gABA 84 9.68 Low Low
cytokine 24 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 48 99.88 Very High Very High Very High
Middle Cerebral Artery Infarction 24 97.84 Very High Very High Very High
Parkinson's Disease 18 97.48 Very High Very High Very High
Cancer 6 89.44 High High
INFLAMMATION 30 5.00 Very Low Very Low Very Low
Convulsion 18 5.00 Very Low Very Low Very Low
Aging 12 5.00 Very Low Very Low Very Low
Overdose 6 5.00 Very Low Very Low Very Low
Epilepsy 6 5.00 Very Low Very Low Very Low
Decapitation 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is unclear whether increased expression of HADH2 in COX-2-/- mice, as observed in the present study, contributed to those previous findings, but it is interesting that mice overexpressing HADH2 and COX-2-/- mice are both resistant to the aforementioned nervous system insults.


Positive_regulation (overexpressing) of Gene_expression (overexpressing) of HADH2 in nervous system
1) Confidence 0.51 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.44 Pain Relevance 0.08
It is unclear whether increased expression of HADH2 in COX-2-/- mice, as observed in the present study, contributed to those previous findings, but it is interesting that mice overexpressing HADH2 and COX-2-/- mice are both resistant to the aforementioned nervous system insults.


Spec (whether) Positive_regulation (increased) of Gene_expression (expression) of HADH2 in nervous system
2) Confidence 0.51 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.47 Pain Relevance 0.07
Expression of HADH2 was determined to be increased in microarray analysis of cerebral cortex of COX-2-/- mice with a z ratio of +1.60.
Positive_regulation (increased) of Gene_expression (Expression) of HADH2 in cerebral cortex associated with cerebral cortex
3) Confidence 0.51 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.39
Transgenic mice overexpressing HADH2 have proved to be more resistant to the brain damage associated with MCAO and MPTP [8,9].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of HADH2 in brain associated with parkinson's disease, targeted disruption and middle cerebral artery infarction
4) Confidence 0.51 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.47 Pain Relevance 0.03
Q-PCR also demonstrated an increase in HADH2 expression (143% ± 24% in COX-2-/- mice versus 100% ± 20% in wild-type mice; t statistic = -3.26, P = 0.01).
Positive_regulation (increase) of Gene_expression (expression) of HADH2
5) Confidence 0.51 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.32
Our findings demonstrate that expressions of HADH2, ACAT1, and ACLY mRNA were upregulated in the cerebral cortex of COX-2-/- mice.
Positive_regulation (upregulated) of Gene_expression (expressions) of HADH2 in cerebral cortex associated with cerebral cortex
6) Confidence 0.37 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.09 Pain Relevance 0.10

General Comments

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