INT205921

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.82
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrb1) plasma membrane (Gabrb1)
Anatomy Link Frequency
hippocampus 2
cerebral cortex 1
Gabrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 108 98.92 Very High Very High Very High
gABA 56 98.28 Very High Very High Very High
GABAergic 20 98.20 Very High Very High Very High
GABA receptor 8 98.08 Very High Very High Very High
cerebral cortex 104 96.36 Very High Very High Very High
Glutamate receptor 4 73.32 Quite High
adenocard 4 65.48 Quite High
cytokine 16 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
Analgesic 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 12 94.12 High High
Epilepsy 4 93.48 High High
Targeted Disruption 32 91.12 High High
Middle Cerebral Artery Infarction 16 12.64 Low Low
Parkinson's Disease 12 12.28 Low Low
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Aging 8 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, our finding that GABRB1 mRNA expression is decreased suggests a downregulation of GABA ionotropic receptor in the hippocampus and cerebral cortex of COX-2-/- mice but not COX-1-/- mice.
Gene_expression (expression) of GABRB1 mRNA in hippocampus associated with gaba, hippocampus and cerebral cortex
1) Confidence 0.69 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.24 Pain Relevance 0.49
We have identified two differentially expressed genes, GABRB1 and GAT3, from the cortical and hippocampal GABAergic system of COX deficient mice.
Gene_expression (expressed) of GABRB1 associated with gabaergic
2) Confidence 0.69 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.26 Pain Relevance 0.32
Validation with Q-PCR demonstrated that the expression of GABRB1 was not only decreased in hippocampus of COX-2-/- mice (54% ± 18% in COX-2-/- mice versus 100% ± 19% in wild-type mice; t statistic = 4.08, P = 0.003) but it was also decreased in cerebral cortex of COX-2-/- mice, a change that was not initially detected by microarray analysis (72% ± 8% in COX-2-/- mice versus 100% ± 17% in wild-type mice; t statistic = 3.67, P = 0.008).
Gene_expression (expression) of GABRB1 in hippocampus associated with hippocampus and cerebral cortex
3) Confidence 0.60 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.09 Pain Relevance 0.50
Therefore, our finding that GABRB1 mRNA expression is decreased suggests a downregulation of GABA ionotropic receptor in the hippocampus and cerebral cortex of COX-2-/- mice but not COX-1-/- mice.
Gene_expression (expression) of GABRB1 mRNA in cerebral cortex associated with gaba, hippocampus and cerebral cortex
4) Confidence 0.23 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.24 Pain Relevance 0.49

General Comments

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