INT20593

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Context Info
Confidence 0.49
First Reported 1983
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.29
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) cell death (Htr2a) aging (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
cortex 2
Htr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 10 99.68 Very High Very High Very High
Serotonin 11 97.76 Very High Very High Very High
Hippocampus 3 97.04 Very High Very High Very High
agonist 11 96.96 Very High Very High Very High
sSRI 5 96.08 Very High Very High Very High
antagonist 9 94.32 High High
midbrain 1 92.08 High High
Thalamus 1 91.52 High High
antidepressant 4 77.80 Quite High
Neurotransmitter 2 71.12 Quite High
Disease Link Frequency Relevance Heat
Convulsion 7 99.78 Very High Very High Very High
Anxiety Disorder 5 95.16 Very High Very High Very High
Urological Neuroanatomy 3 88.52 High High
Depression 2 68.44 Quite High
Shock 1 51.16 Quite High
Dysmenorrhea 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results support earlier evidence that serum corticosterone concentration in rats can be increased by activation of either 5-HT1A or 5-HT2 receptors.
Positive_regulation (increased) of Positive_regulation (activation) of 5-HT2
1) Confidence 0.49 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2148812 Disease Relevance 0 Pain Relevance 0.68
Although the results suggest that selective stimulation of 5-HT1A and 5-HT2A receptors produces a decrease of USV, we postulate that only 5-HT2A receptors play a pivotal role in the effects of SSRIs in this model of anxiety.
Positive_regulation (produces) of Positive_regulation (stimulation) of 5-HT2A associated with anxiety disorder and ssri
2) Confidence 0.49 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9539263 Disease Relevance 0.38 Pain Relevance 0.36
The results obtained indicate that: (a) activation of 5-HT1A receptors stimulated PRL secretion on day 16 and inhibited it on day 23; activation of 5-HT2 receptors stimulated PRL secretion on days 16 and 23, whereas activation of 5-HT3 receptors inhibited PRL release only on day 23; (b) activation of AMPA receptors inhibited PRL secretion on day 23, but not on day 16 and (c) a cross-talk is apparent between 5-HT2 and AMPA receptors in the regulation of PRL secretion, the stimulatory effect of DOI being blocked by AMPA.
Positive_regulation (stimulated) of Positive_regulation (activation) of 5-HT2
3) Confidence 0.49 Published 2001 Journal J. Physiol. Biochem. Section Abstract Doc Link 11800286 Disease Relevance 0 Pain Relevance 0.45
Progesterone alone caused a smaller increase in 5HT2 receptors, a similar decrease in 5HT1 and had no significant effect on noradrenergic receptors.
Positive_regulation (caused) of Positive_regulation (increase) of 5HT2
4) Confidence 0.45 Published 1983 Journal Life Sci. Section Abstract Doc Link 6188018 Disease Relevance 0 Pain Relevance 0.11
Fluoxetine treatment also resulted in upregulation of 5-HT2 receptors in layers of frontoparietal cortex (31-38%) and in CA2-3 fields of hippocampus (by 39%).
Positive_regulation (resulted) of Positive_regulation (upregulation) of 5-HT2 in cortex associated with hippocampus and fluoxetine
5) Confidence 0.45 Published 1993 Journal Synapse Section Abstract Doc Link 8248854 Disease Relevance 0.07 Pain Relevance 0.67
ECS treatment resulted in a similar time-dependent up-regulation of 5-HT2 receptor ligand binding; chronic, but not acute, ECS treatment significantly increased levels of [3H]ketanserin ligand binding, confirming previous reports.
Positive_regulation (resulted) of Positive_regulation (up-regulation) of 5-HT2 associated with convulsion
6) Confidence 0.45 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.84 Pain Relevance 0.28

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