INT205952

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 14
Total Number 18
Disease Relevance 2.46
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
anterior 2
vestibular hair cells 1
pore 1
epithelial cells 1
endothelial cells 1
Shbdp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatosensory cortex 210 100.00 Very High Very High Very High
lidocaine 44 98.32 Very High Very High Very High
Eae 12 85.20 High High
anesthesia 8 75.08 Quite High
Pyramidal cell 10 68.96 Quite High
Action potential 92 66.08 Quite High
monoamine 16 62.88 Quite High
agonist 14 57.20 Quite High
action potential duration 24 56.84 Quite High
Dopamine 150 56.60 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 69 99.78 Very High Very High Very High
Malaria 1 99.06 Very High Very High Very High
Immunization 29 96.96 Very High Very High Very High
Syndrome 24 92.48 High High
Pressure And Volume Under Development 18 92.28 High High
Convulsion 4 91.48 High High
Dyskinesias 32 87.68 High High
Hypokalemia 83 87.28 High High
Tremor 6 78.92 Quite High
Myocardial Infarction 7 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, S2 stimulation did not result in arrhythmic activity in lidocaine-treated hearts whatever the S1S2 interval, whether under normokalemic (Fig. 2c, A–C, n?
Gene_expression (stimulation) of S2 in hearts associated with lidocaine
1) Confidence 0.24 Published 2007 Journal Pflugers Arch Section Body Doc Link PMC1839769 Disease Relevance 0.37 Pain Relevance 0.25
GST-tagged gelsolin constructs containing either S1 and S2 (P1), S3 and S4 (P2) or S5 and S6 (P3) gelsolin domains were expressed in E. coli K12 ER2508 cells using pGEX-4T1.
Gene_expression (expressed) of S2 in 4T1
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
We found that GST fusions with the S1/S2, the S3/S4 and S5/S6 domains of gelsolin pulled down the p55 GUK domain (Fig. 1c).


Gene_expression (fusions) of S2
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.05 Pain Relevance 0
We found that GST fusions with the S1/S2, the S3/S4 and S5/S6 domains of gelsolin pulled down the p55 GUK domain (Fig. 1c).


Gene_expression (domains) of S2
4) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.05 Pain Relevance 0
Since this functional division was not clear in S2, L2/3 was divided in half.
Neg (not) Spec (clear) Gene_expression (clear) of S2 associated with somatosensory cortex
5) Confidence 0.17 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.12
0.7–1.3 mm anterior to bregma were used; for vS1 and S2 slices, the brain was cut coronally, and slices ?
Gene_expression (vS1) of S2 in anterior associated with somatosensory cortex
6) Confidence 0.17 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.18
0.7–1.3 mm anterior to bregma were used; for vS1 and S2 slices, the brain was cut coronally, and slices ?
Gene_expression (slices) of S2 in anterior associated with somatosensory cortex
7) Confidence 0.17 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.18
L5 projection identified in S2 was more than twice as strong at the neuron?
Gene_expression (identified) of S2 in neuron associated with somatosensory cortex
8) Confidence 0.17 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.13
L2/3 in vS1 and S2; L5A?
Gene_expression (vS1) of S2 associated with somatosensory cortex
9) Confidence 0.17 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.17
An explanation of these changes, as well as a list of rate constants, can be found in Figure S7 (also see Protocols S1 and S2).
Gene_expression (see) of S2
10) Confidence 0.16 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2953532 Disease Relevance 0 Pain Relevance 0
Finally, we investigated the expression of gelsolin in the vestibular system and found that gelsolin was absent in vestibular hair cells (Supplementary Information Figure S2).


Neg (absent) Gene_expression (absent) of S2 in vestibular hair cells
11) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
S2 C) and for remaining T and B lymphocytes to regain wild-type levels of surface integrin expression (Fig.
Gene_expression (expression) of S2 in B lymphocytes
12) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.34 Pain Relevance 0
As presented in the Supplemental Figure S2, i.c.v. infusion of 3-MT (9 µg) caused potent elevation of 3-MT concentrations in striatal dialysates with maximal levels approaching 100 nM.

3-MT activates TAAR1-mediated signaling in vitro

Gene_expression (presented) of S2
13) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.11 Pain Relevance 0.13
Examples of behavioral effects of 3-MT (36 µg, 40 min after administration) in normal mice of mixed 129SvJ/C57BL6 background (wild type littermate controls for TAAR1-KO mice) are presented in the Supplemental Videos S1 and S2.
Gene_expression (presented) of S2 associated with targeted disruption
14) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.82 Pain Relevance 0.10
Resistance to malaria is an unlikely factor, since ankyrin-B is not expressed in erythrocytes (not shown), or in vascular endothelial cells (Figure S2), and since variants are present in both Africans and Europeans.
Neg (not) Gene_expression (expressed) of S2 in endothelial cells associated with malaria
15) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.48 Pain Relevance 0
In contrast, SLC5A12 is expressed also in the apical membrane of tubular epithelial cells but its expression is evident all along the proximal tubule (S1, S2, and S3 segments) (14).
Gene_expression (expression) of S2 in epithelial cells
16) Confidence 0.04 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0 Pain Relevance 0
The PCs/PCl ratio in rescued cells overexpressing wild-type dBest1 was the same as the native S2 current regardless of MTSES?
Gene_expression (current) of S2
17) Confidence 0.03 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0 Pain Relevance 0
However, the rescue experiment alone does not formally prove that dBest1 is the pore-forming subunit of the S2 volume-regulated anion channel (VRAC) because overexpression of an essential regulator or accessory subunit of the channel could have the same effect.
Gene_expression (overexpression) of S2 in pore
18) Confidence 0.03 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0.21 Pain Relevance 0

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