INT205968

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PTCH1) Golgi apparatus (PTCH1) plasma membrane (PTCH1)
PTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 1 19.84 Low Low
tolerance 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Breast Cancer 55 99.32 Very High Very High Very High
Cancer 58 98.68 Very High Very High Very High
Pancreatic Cancer 2 97.48 Very High Very High Very High
Rhabdomyosarcoma 1 96.68 Very High Very High Very High
Glioblastoma 1 95.92 Very High Very High Very High
Medulloblastoma 11 95.32 Very High Very High Very High
Basal Cell Nevus Syndrome 5 90.40 High High
Skin Cancer 16 83.88 Quite High
Fanconi Anemia 2 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent report suggested loss of PTCH1 in 19% of human breast cancers, and 33% of breast cancer cell lines [9].
Negative_regulation (loss) of PTCH1 associated with breast cancer
1) Confidence 0.58 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 1.79 Pain Relevance 0
Gli1 activates Ptc1 expression and thus counters, to some extent Shh repression of Ptc1 activity [33,35,38].
Negative_regulation (repression) of Ptc1 associated with repression
2) Confidence 0.38 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.56 Pain Relevance 0

General Comments

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