INT205969

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.09
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GLI1) nucleus (GLI1) intracellular (GLI1)
DNA binding (GLI1) cytoplasm (GLI1)
Anatomy Link Frequency
skin 2
SK-OV-3 1
GLI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 8 73.76 Quite High
antagonist 2 46.76 Quite Low
Chronic pancreatitis 1 9.28 Low Low
headache 8 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 232 98.76 Very High Very High Very High
Medulloblastoma 10 97.24 Very High Very High Very High
Glioma 3 90.84 High High
Repression 3 90.00 High High
Hyponatremia 2 81.36 Quite High
Fatigue 18 80.00 Quite High
Liver Cancer 1 75.28 Quite High
Basal Cell Neoplasms 10 74.48 Quite High
Disease 34 74.24 Quite High
Solid Tumor 12 73.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of particular interest is regulation of the Gli family of transcription factors that are believed to be involved in medulloblastoma tumorigenesis [26,28,29,33].
Regulation (regulation) of Gli associated with medulloblastoma
1) Confidence 0.41 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.67 Pain Relevance 0
Skin punch biopsies were used to illustrate down-regulation of Gli1, a transcription factor activated by SMO, the target of GDC-0449.
Regulation (regulation) of Gli1 in Skin
2) Confidence 0.36 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.59 Pain Relevance 0.04
Down-modulation of Gli 1 transcription factor was observed in all skin punch biopsy samples after treatment with GDC-0449.
Regulation (modulation) of Gli 1 in skin
3) Confidence 0.36 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.92 Pain Relevance 0
Their objective was to determine whether or not synthetic miRNA targeting Gli-1 mRNA could be used to inhibit tumor cell proliferation in ovarian SK-OV-3 and pancreatic MiaPaCa-2.
Regulation (targeting) of Gli-1 in SK-OV-3 associated with cancer
4) Confidence 0.11 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.91 Pain Relevance 0

General Comments

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