INT205972

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GLI1) nucleus (GLI1) intracellular (GLI1)
DNA binding (GLI1) cytoplasm (GLI1)
GLI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Medulloblastoma 20 99.28 Very High Very High Very High
Cancer 64 98.60 Very High Very High Very High
Repression 6 92.20 High High
Disease 6 12.04 Low Low
Brain Tumor 4 10.16 Low Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
Cerebral Palsy 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Disease Progression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The feedback from Gli1 to Ptc1 that is active in normal cells, as illustrated by figure 2, may play an important role in determining the effectiveness of drugs that regulate Gli1 expression downstream of Smo.
Regulation (regulate) of Gene_expression (expression) of Gli1
1) Confidence 0.41 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.59 Pain Relevance 0
Several promising cancer drugs that reduce medulloblastoma growth in mouse models purportedly interfere with Gli1 and Gli2 expression by blocking the signalling pathway downstream of Smo.
Regulation (interfere) of Gene_expression (expression) of Gli1 associated with cancer and medulloblastoma
2) Confidence 0.30 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.58 Pain Relevance 0

General Comments

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