INT205973

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.03
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (SHH) endoplasmic reticulum (SHH) embryo development (SHH)
cell-cell signaling (SHH) signal transducer activity (SHH) peptidase activity (SHH)
SHH (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 1 76.20 Quite High
Somatostatin 3 68.36 Quite High
Glutamate 8 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 93.84 High High
Medulloblastoma 40 90.08 High High
Basal Cell Carcinoma 46 89.24 High High
Basal Cell Nevus Syndrome 88 87.84 High High
Cancer 73 87.60 High High
Adrenal Cancer 1 42.68 Quite Low
Adenoid Cystic Carcinoma 1 41.16 Quite Low
Adenoma 1 39.68 Quite Low
Neurilemmoma 1 38.80 Quite Low
Seminoma 1 37.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Frizzled receptors are found in all bilateral species and are crucial for early embryonic development while being the receptor for Wnt and Sonic hedgehog.
Sonic hedgehog Binding (receptor) of
1) Confidence 0.35 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2246102 Disease Relevance 0 Pain Relevance 0.07
It encodes a transmembrane glycoprotein composed of 1447 amino acids, with 12 transmembrane domains and two large hydrophilic extracellular loops where Sonic Hedgehog (SHH) ligand binding occurs.
Sonic Hedgehog Binding (binding) of
2) Confidence 0.35 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 0.47 Pain Relevance 0
A target of Gli1 is PTC1; Ptc1 is a transmembrane protein that blocks Smo expression when Shh binds to it.
Shh Binding (binds) of
3) Confidence 0.28 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.57 Pain Relevance 0

General Comments

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