INT205984

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8, Map3k12) cytoplasm (Mapk8, Map3k12) signal transduction (Mapk8)
mitochondrion (Mapk8) plasma membrane (Map3k12) nucleus (Mapk8)
Anatomy Link Frequency
neuronal 1
Mapk8 (Rattus norvegicus)
Map3k12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 33 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 29 73.68 Quite High
Stress 4 48.08 Quite Low
Heart Disease 13 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Hepatotoxicity 4 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 4 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The high dosed 6 hrs rats differed from the high dosed 18, 24 and 48 hrs rats by a small cluster of genes that include an activator (Mitogen activated protein kinase kinase kinase 12 [Map3k12]) of the c-Jun N-terminal kinase (JNK) pathway, a transactivator of thyroid-stimulating hormone beta, and a regulator of neuronal differentiation and development.



JNK Positive_regulation (activated) of Map3k12 in neuronal
1) Confidence 0.15 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839893 Disease Relevance 0.24 Pain Relevance 0

General Comments

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