INT205992

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.81
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC7A7) plasma membrane (SLC7A7) protein complex assembly (SLC7A7)
transmembrane transport (SLC7A7) cellular amino acid metabolic process (SLC7A7)
Anatomy Link Frequency
macrophages 2
external 2
SLC7A7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 2 16.56 Low Low
tolerance 1 10.00 Low Low
agonist 8 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Cannabinoid receptor 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Endocannabinoid 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 84 100.00 Very High Very High Very High
Respiratory Failure 11 80.40 Quite High
Pneumonia 5 45.76 Quite Low
Granuloma 7 45.36 Quite Low
Recurrence 4 40.88 Quite Low
Systemic Lupus Erythematosus 1 37.64 Quite Low
Congenital Anomalies 5 34.84 Quite Low
Bone Disease 2 25.36 Quite Low
Angina 2 16.56 Low Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GM-CSF induces comparable changes in gene expression also in LPI macrophages, where, however, due to the SLC7A7 mutation, no increase in system y+L activity is observed.
Spec (observed) Regulation (observed) of Neg (no) Gene_expression (mutation) of SLC7A7 in macrophages
1) Confidence 0.44 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.09 Pain Relevance 0
LPI elicits biphasic Ca2+ elevation, accompanied by diverse changes in membrane potential
Regulation (biphasic) of Gene_expression (elevation) of LPI
2) Confidence 0.16 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0 Pain Relevance 0
In addition, mutations of surfactant protein B gene and other known external or syndromic causes of PAP, including LPI, were ruled out in this cohort of paediatric patients.
Regulation (ruled) of Gene_expression (mutations) of LPI in external associated with pulmonary alveolar proteinosis
3) Confidence 0.07 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1845139 Disease Relevance 0.71 Pain Relevance 0

General Comments

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