INT205994

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.44
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC7A7) plasma membrane (SLC7A7) protein complex assembly (SLC7A7)
transmembrane transport (SLC7A7) cellular amino acid metabolic process (SLC7A7)
Anatomy Link Frequency
monocytes 3
SLC7A7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 95.80 Very High Very High Very High
Angina 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rare Diseases 3 100.00 Very High Very High Very High
Pulmonary Alveolar Proteinosis 154 89.68 High High
Disease 8 89.20 High High
Renal Disease 7 88.36 High High
Intellectual Impairment 1 86.44 High High
Coma 1 85.64 High High
Osteoporosis 5 84.92 Quite High
Congenital Anomalies 9 84.36 Quite High
Failure To Thrive 4 82.48 Quite High
Diarrhoea 1 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 5, SLC7A7 mRNA was highly expressed in monocytes and even more in AM, both from normal donors and from the LPI patient, while it appears extremely low in fibroblasts.
Transcription (expressed) of SLC7A7 in monocytes
1) Confidence 0.70 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
As shown in Figure 5, SLC7A7 mRNA was highly expressed in monocytes and even more in AM, both from normal donors and from the LPI patient, while it appears extremely low in fibroblasts.
Transcription (expressed) of LPI in monocytes
2) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
However, also the monocytes from the LPI subject responded to rGM-CSF with a 2-fold increase in SLC7A7 mRNA level, although system y+L transport activity remained unaffected.
Transcription (level) of SLC7A7 in monocytes
3) Confidence 0.52 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.05
LPI is a very rare disease which was first described in 1965 in two infant Finnish siblings [9].
Transcription (described) of LPI associated with rare diseases
4) Confidence 0.10 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1845139 Disease Relevance 1.44 Pain Relevance 0

General Comments

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