INT205995

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 11
Total Number 45
Disease Relevance 10.61
Pain Relevance 1.21

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transport (SLC7A7) plasma membrane (SLC7A7) protein complex assembly (SLC7A7)
transmembrane transport (SLC7A7) cellular amino acid metabolic process (SLC7A7)
Anatomy Link Frequency
monocytes 11
macrophages 10
fibroblasts 5
alveolar macrophages 4
plasma 2
SLC7A7 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 48 100.00 Very High Very High Very High
cytokine 108 98.16 Very High Very High Very High
withdrawal 6 95.40 Very High Very High Very High
antagonist 6 81.36 Quite High
Cannabinoid receptor 12 74.08 Quite High
Endocannabinoid 6 68.56 Quite High
fibrosis 9 56.88 Quite High
Angina 36 54.60 Quite High
tolerance 1 10.00 Low Low
cva 36 6.44 Low Low
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 1274 100.00 Very High Very High Very High
Granuloma 41 99.92 Very High Very High Very High
Toxicity 13 99.36 Very High Very High Very High
Targeted Disruption 31 97.78 Very High Very High Very High
Sickle Cell Anemia 96 96.92 Very High Very High Very High
Thalassemia 64 96.60 Very High Very High Very High
Cancer 13 96.16 Very High Very High Very High
Hypertension 27 92.36 High High
Leukocytosis 35 90.84 High High
Iron Overload 67 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The comparison between SLC7A7 and SLC7A6 expression levels indicated that in normal monocytes SLC7A7 mRNA was 30-fold more expressed than SLC7A6 (0.021 ± 0.005 molecules SLC7A7/RPL15 vs 0.0007 ± 0.00004 molecules SLC7A6/RPL15).
Gene_expression (expression) of SLC7A7 in monocytes
1) Confidence 0.75 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
If this positive evolution were to be ascribed to GM-CSF, we should assume that GM-CSF therapy increases also in vivo the expression of genes, other than SLC7A7, involved in surfactant catabolism.
Gene_expression (expression) of SLC7A7
2) Confidence 0.75 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.37 Pain Relevance 0
Whereas no information is yet available on SLC7A7 expression and function in lymphoid populations, the high expression and activity of SLC7A7 in normal macrophages and the substantial defect in system y+L activity observed in LPI macrophages support the hypothesis of a pathogenetic role of these cells in the development of LPI-associated immunological disorders.
Gene_expression (expression) of SLC7A7 in macrophages
3) Confidence 0.75 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.17 Pain Relevance 0
The expression of Slc7a7 (an important basolateral arginine transporter) was decreased in 2 days SHR vs.
Gene_expression (expression) of Slc7a7
4) Confidence 0.75 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.19 Pain Relevance 0
Expression of mRNA for system y+L transporters in monocytes, alveolar macrophages and fibroblasts of the LPI patient
Gene_expression (Expression) of LPI in fibroblasts
5) Confidence 0.66 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
GM-CSF induces comparable changes in gene expression also in LPI macrophages, where, however, due to the SLC7A7 mutation, no increase in system y+L activity is observed.
Neg (no) Gene_expression (mutation) of SLC7A7 in macrophages
6) Confidence 0.65 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.09 Pain Relevance 0
Whereas no information is yet available on SLC7A7 expression and function in lymphoid populations, the high expression and activity of SLC7A7 in normal macrophages and the substantial defect in system y+L activity observed in LPI macrophages support the hypothesis of a pathogenetic role of these cells in the development of LPI-associated immunological disorders.
Gene_expression (expression) of SLC7A7 in macrophages
7) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.17 Pain Relevance 0
Moreover, the expression of SLC7A7 is regulated by GM-CSF in monocytes, pointing to a role of y+LAT1 in the pathogenesis of LPI associated PAP.



Gene_expression (expression) of SLC7A7 in monocytes associated with pulmonary alveolar proteinosis
8) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2999609 Disease Relevance 0.18 Pain Relevance 0.04
We have found that: 1) system y+L activity is markedly lowered in monocytes and alveolar macrophages from the LPI patient, because of the prevailing expression of SLC7A7/y+LAT1 in these cells; 2) on the contrary, fibroblasts isolated from the same patient do not display the transport defect due to compensation by the SLC7A6/y+LAT2 isoform; 3) in both normal and LPI monocytes, GM-CSF induces the expression of SLC7A7, suggesting that the gene is a target of the cytokine; 4) GM-CSF-induced differentiation of LPI monocytes is comparable to that of normal cells, demonstrating that GM-CSF signalling is unaltered; 5) general and respiratory conditions of the patient, along with PAP-associated parameters, markedly improved after GM-CSF therapy through aerosolization.


Gene_expression (expression) of SLC7A7 in monocytes associated with pulmonary alveolar proteinosis and cytokine
9) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2999609 Disease Relevance 0.34 Pain Relevance 0.04
We have found that: 1) in AM isolated from the WLL fluid of the LPI patient and in peripheral blood monocytes from the same subject system y+L activity is markedly reduced compared to controls; 2) conversely, mesenchymal cells, isolated from the same patient, do not display the transport defect, consistently with our previous results [25]; 3) in both normal and LPI monocytes the expression of SLC7A7 is induced by GM-CSF, suggesting that the transporter gene is a target of the cytokine; 4) GM-CSF induces genes coding for specialized macrophage functions in both normal and LPI monocytes.
Gene_expression (expression) of SLC7A7 in mesenchymal cells associated with cytokine
10) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.08
Consistently, we demonstrated high expression of SLC7A7 in human peripheral monocytes and in human alveolar macrophages (AM), as well as system y+L as the only functional transport activity for CAA in these cell models [15,16].
Gene_expression (expression) of SLC7A7 in alveolar macrophages
11) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.98 Pain Relevance 0
The different transport phenotypes are referable to the relative levels of expression of SLC7A7 and SLC7A6.
Gene_expression (expression) of SLC7A7
12) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2999609 Disease Relevance 0.09 Pain Relevance 0.04
We have found that: 1) system y+L activity is markedly lowered in monocytes and alveolar macrophages from the LPI patient, because of the prevailing expression of SLC7A7/y+LAT1 in these cells; 2) on the contrary, fibroblasts isolated from the same patient do not display the transport defect due to compensation by the SLC7A6/y+LAT2 isoform; 3) in both normal and LPI monocytes, GM-CSF induces the expression of SLC7A7, suggesting that the gene is a target of the cytokine; 4) GM-CSF-induced differentiation of LPI monocytes is comparable to that of normal cells, demonstrating that GM-CSF signalling is unaltered; 5) general and respiratory conditions of the patient, along with PAP-associated parameters, markedly improved after GM-CSF therapy through aerosolization.


Gene_expression (expression) of SLC7A7 in monocytes associated with pulmonary alveolar proteinosis and cytokine
13) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2999609 Disease Relevance 0.21 Pain Relevance 0.05
As far as system y+L activity is concerned, the different phenotype displayed by LPI monocytes/macrophages and fibroblasts can be explained by the relative level of expression of SLC7A7 and SLC7A6 in these models.
Gene_expression (expression) of SLC7A7 in monocytes
14) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.04
SLC7A6, SLC7A7 and RPL15 expression levels are given as numbers of mRNA molecules [19].
Gene_expression (expression) of SLC7A7
15) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
The high level of SLC7A7 expression found in these cells strengthens the hypothesis that y+LAT1 defect in macrophages plays an important role in the pathogenesis of LPI-associated PAP.
Gene_expression (expression) of SLC7A7 in macrophages associated with pulmonary alveolar proteinosis
16) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.83 Pain Relevance 0
To assess if a different pattern of expression of SLC7A7/y+LAT1 and SLC7A6/y+LAT2 in LPI monocytes, macrophages and fibroblasts may justify the different transport phenotype of these cells, the expression of both genes was evaluated as number of mRNA molecules.
Gene_expression (expression) of SLC7A7 in monocytes
17) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
Moreover, 12 months after the end of rGM-CSF administration no granulomatous disorder appeared, in contrast with findings by Douda, who had showed that GM-CSF promoted the spontaneous formation of granulomas by LPI alveolar macrophages in vitro [41].
Gene_expression (alveolar macrophages) of LPI in alveolar macrophages associated with granuloma
18) Confidence 0.57 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.53 Pain Relevance 0
Conversely, the activity of system y+L was readily detectable in LPI fibroblast-like mesenchymal cells and comparable to that observed in normal human fibroblasts.
Gene_expression (detectable) of LPI in mesenchymal cells
19) Confidence 0.57 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0
However, we show here that GM-CSF induces comparable morphological phenotypes and expression patterns of differentiation markers in macrophages from LPI patient and healthy subjects.
Gene_expression (expression) of LPI in macrophages
20) Confidence 0.57 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.29 Pain Relevance 0

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