INT206006

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.63
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxm1) embryo development (Foxm1) DNA binding (Foxm1)
transcription factor binding (Foxm1) cytoplasm (Foxm1)
Anatomy Link Frequency
endocrine cells 2
lobe 2
Foxm1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 13 99.84 Very High Very High Very High
Inflammation 96 98.24 Very High Very High Very High
tolerance 6 85.32 High High
Inflammatory stimuli 1 57.20 Quite High
Potency 1 39.36 Quite Low
psoriasis 3 29.68 Quite Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 93 100.00 Very High Very High Very High
Cancer 71 100.00 Very High Very High Very High
Disease 18 98.60 Very High Very High Very High
INFLAMMATION 93 98.24 Very High Very High Very High
Targeted Disruption 13 98.04 Very High Very High Very High
Hypertrophy 2 92.96 High High
Contact Dermatitis 29 92.24 High High
Impaired Glucose Tolerance 6 85.32 High High
Urological Neuroanatomy 10 74.96 Quite High
Aging 2 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FoxM1 is highly expressed within pancreatic endocrine cells during embryogenesis and is downregulated with age (9), corresponding with reduced ?
Negative_regulation (downregulated) of Gene_expression (expressed) of FoxM1 in endocrine cells
1) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.41 Pain Relevance 0.04
-cell size was significantly reduced specifically within the splenic lobe of FoxM1?
Negative_regulation (reduced) of Gene_expression (lobe) of FoxM1 in lobe
2) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.09 Pain Relevance 0
Indeed, it was demonstrated that MPM reduced production of cytokine TNF?
Negative_regulation (reduced) of Gene_expression (production) of MPM associated with cytokine
3) Confidence 0.30 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1845142 Disease Relevance 1.13 Pain Relevance 0.52
The TUSC2 locus is frequently deleted in MPM tumors
Negative_regulation (deleted) of Gene_expression (tumors) of MPM associated with lung cancer and cancer
4) Confidence 0.02 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 1.00 Pain Relevance 0

General Comments

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