INT206007

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.32
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd79a)
Anatomy Link Frequency
lymphocytes 4
T-cell 2
Cd79a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 76 99.30 Very High Very High Very High
Bile 20 97.26 Very High Very High Very High
Inflammation 105 88.64 High High
Inflammatory response 3 63.92 Quite High
chemokine 3 22.40 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 5 94.52 High High
Cancer 3 94.16 High High
Influenza Virus Infection 68 90.32 High High
INFLAMMATION 103 88.64 High High
Hypersensitivity 5 82.80 Quite High
Immunization 77 82.60 Quite High
Obstructive Jaundice 14 82.56 Quite High
Pneumonia 2 82.24 Quite High
Severe Acute Respiratory Syndrome 7 80.96 Quite High
Respiratory Syncytial Virus 3 70.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of enhancement of IgA response by HET still remains obscure.
Positive_regulation (enhancement) of Localization (response) of IgA
1) Confidence 0.35 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.05 Pain Relevance 0
Note: in our preliminary experiment, the administration of OVA free blank microparticles did not induce IgA immune response in gastric mucosa (data not shown).
Neg (not) Positive_regulation (induce) of Localization (response) of IgA
2) Confidence 0.35 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.21 Pain Relevance 0
HET might modulate cytokine secretion of IEC, and the mucosal IgA antibody secretion might be enhanced through action of these cytokines.
Positive_regulation (enhanced) of Localization (secretion) of IgA associated with cytokine
3) Confidence 0.35 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.31 Pain Relevance 0.27
These observations suggest that a lack of bile juice changed the intestinal flora, thereby stimulating Th2-type lymphocytes in the intestinal mucosa to produce IL-10 and subsequently increase IgA secretion.
Positive_regulation (increase) of Localization (secretion) of IgA in lymphocytes associated with bile
4) Confidence 0.24 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0.51 Pain Relevance 0.23
Mucosal, as opposed to systemic vaccination is often more efficacious against mucosal pathogens due to their ability to induce secretory IgA [1], [2].
Positive_regulation (induce) of Localization (secretory) of IgA
5) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.51 Pain Relevance 0.07
Whey peptides have recently been shown to possess immunomodulatory activities such as a stimulation of lymphocytes, an increasing in phagocytosis process as well as in secretion of immunoglobulin A (IgA) by Peyer's patches [5,13,17,20].
Positive_regulation (increasing) of Localization (secretion) of IgA in lymphocytes
6) Confidence 0.17 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1845142 Disease Relevance 0.97 Pain Relevance 0.24
Live attenuated intranasal and VLP vaccines that are capable of inducing secretory IgA and T-cell immunity are considered as a possible solution for obtaining broader protection against subtype specific antigenic variants.
Positive_regulation (inducing) of Localization (secretory) of IgA in T-cell
7) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694350 Disease Relevance 0.76 Pain Relevance 0

General Comments

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