INT206025

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.95
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
myeloid cells 2
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 15 97.72 Very High Very High Very High
Angina 5 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 72 99.36 Very High Very High Very High
Pulmonary Alveolar Proteinosis 170 92.92 High High
Congenital Anomalies 16 91.56 High High
Failure To Thrive 15 82.36 Quite High
Growth Problems 5 78.52 Quite High
Respiratory Failure 10 73.00 Quite High
Brain Disease 1 70.00 Quite High
Disease 26 69.04 Quite High
Syndrome 10 65.88 Quite High
Chromosome Aberrations 5 54.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No longer does the CSF compartment as assessed by HIV RNA and immune activation markers such as ?
Negative_regulation (does) of CSF Neg (No) Binding (compartment) of associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.29 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.30 Pain Relevance 0
The combination of a negative GM-CSF autoantibody test (29) and an abnormal CD11b stimulation index (24) predicted the GM-CSF receptor dysfunction, which was confirmed by the lack of GM-CSF binding and defective GM-CSF receptor signaling.
Negative_regulation (lack) of GM-CSF Binding (binding) of
2) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.76 Pain Relevance 0
, alters a potential site of glycosylation and impairs GM-CSF binding and receptor signaling.
Negative_regulation (impairs) of GM-CSF Binding (binding) of
3) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.15 Pain Relevance 0.05
chain was structurally abnormal, which severely reduced but did not completely abolish GM-CSF binding and GM-CSF–dependent signaling and cellular functions.


Negative_regulation (reduced) of GM-CSF Binding (binding) of
4) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.08 Pain Relevance 0
, severely reducing GM-CSF binding, receptor signaling, and GM-CSF–dependent functions in primary myeloid cells.
Negative_regulation (reducing) of GM-CSF Binding (binding) of in myeloid cells
5) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2585845 Disease Relevance 0.59 Pain Relevance 0.05
chain was structurally abnormal, which severely reduced but did not completely abolish GM-CSF binding and GM-CSF–dependent signaling and cellular functions.


Neg (not) Negative_regulation (abolish) of GM-CSF Binding (binding) of
6) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.08 Pain Relevance 0

General Comments

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