INT20603

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 32.61
Pain Relevance 11.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNFRSF10B)
Anatomy Link Frequency
chondrocyte 1
colon 1
cleavage 1
LAK cell 1
LGL 1
TNFRSF10B (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 269 99.82 Very High Very High Very High
qutenza 62 99.70 Very High Very High Very High
Enkephalin 30 99.32 Very High Very High Very High
cytokine 28 98.76 Very High Very High Very High
Arthritis 55 98.64 Very High Very High Very High
Morphine 3 98.64 Very High Very High Very High
cINOD 90 98.54 Very High Very High Very High
tramadol 7 98.16 Very High Very High Very High
antagonist 220 97.00 Very High Very High Very High
opioid receptor 1 96.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 358 100.00 Very High Very High Very High
Apoptosis 1753 99.90 Very High Very High Very High
Stress 28 99.64 Very High Very High Very High
Glioma 36 99.40 Very High Very High Very High
Rheumatoid Arthritis 77 98.64 Very High Very High Very High
Reprotox - General 1 53 98.28 Very High Very High Very High
Renal Cancer 21 97.20 Very High Very High Very High
Cancer 942 96.92 Very High Very High Very High
Necrosis 35 96.68 Very High Very High Very High
Colon Cancer 189 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac sulfide up-regulated DR5 and activated the proximal caspase 8 in various different colon and prostate cancer cell lines.
Positive_regulation (regulated) of DR5 in colon associated with reprotox - general 1
1) Confidence 0.67 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11559570 Disease Relevance 1.39 Pain Relevance 0.08
Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells.
Positive_regulation (induction) of DR5 associated with hepatocellular cancer, apoptosis and cytokine
2) Confidence 0.67 Published 2008 Journal Oncol. Rep. Section Title Doc Link 18202802 Disease Relevance 0.94 Pain Relevance 0.05
SC-'236 also upregulates DR5 in both Bax-proficient and Bax-deficient cells but Apo2L/TRAIL potentiates SC-'236-mediated apoptosis and caspases-8 and -3 activation in both Bax-proficient and Bax-deficient cells.
Positive_regulation (upregulates) of DR5 associated with apoptosis
3) Confidence 0.67 Published 2002 Journal Oncogene Section Abstract Doc Link 12203115 Disease Relevance 1.12 Pain Relevance 0.36
We further show that sulindac sulfide and SC-'236-induced DR5 upregulation occurs independent of the COX inhibitory effects of these NSAIDs.
Positive_regulation (upregulation) of DR5 associated with cinod
4) Confidence 0.67 Published 2002 Journal Oncogene Section Abstract Doc Link 12203115 Disease Relevance 1.06 Pain Relevance 0.46
We show that sulindac sulfide and SC-'236-induced apoptosis is coupled with upregulation of DR5, caspase 8 activation and Bid cleavage.
Positive_regulation (upregulation) of DR5 in cleavage associated with apoptosis
5) Confidence 0.67 Published 2002 Journal Oncogene Section Abstract Doc Link 12203115 Disease Relevance 1.02 Pain Relevance 0.46
For example, sulindac sulfide upregulates DR5 in both Bax-deficient and proficient cells, but Apo2L/TRAIL efficiently potentiates sulindac sulfide-induced apoptosis as well as activation of caspase-8, -9 and -3 only in Bax-proficient cells.
Positive_regulation (upregulates) of DR5 associated with apoptosis
6) Confidence 0.58 Published 2002 Journal Oncogene Section Abstract Doc Link 12203115 Disease Relevance 1.08 Pain Relevance 0.40
Sulindac sulfide specifically up-regulated the DR5 levels but had no effect on the levels of other DRs including DR4, Fas, and tumor necrosis factor receptor 1.
Positive_regulation (up-regulated) of DR5 associated with necrosis and cancer
7) Confidence 0.49 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11559570 Disease Relevance 1.59 Pain Relevance 0.07
The salient points of various stages of this study are: low frequency of HLA-B14 antigen with, in contrast, high frequency of the HLA-DR5 antigen of the major histocompatibility system.
Positive_regulation (frequency) of DR5
8) Confidence 0.49 Published 1990 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 2150489 Disease Relevance 0.68 Pain Relevance 0.68
These findings demonstrate that b-end enhances NK activity and IFN production of purified LGL, and suggests that b-end might bind to an opioid receptor on LGL that can be blocked by naloxone.
Positive_regulation (enhances) of NK in LGL associated with narcan and opioid receptor
9) Confidence 0.49 Published 1986 Journal J. Immunol. Section Abstract Doc Link 2934481 Disease Relevance 0 Pain Relevance 0.26
At effector:target cell ratios of 100:1, 33:1 and 11:1 leucine-enkephalin significantly (p less than 0.05) enhanced NK activity at dilutions of 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml.
Positive_regulation (enhanced) of NK associated with enkephalin
10) Confidence 0.49 Published 1987 Journal Nat. Immun. Cell Growth Regul. Section Abstract Doc Link 3600678 Disease Relevance 0.25 Pain Relevance 0.69
The enhancement of NK activity with beta-endorphin increased at all E:T ratios tested.
Positive_regulation (enhancement) of NK
11) Confidence 0.49 Published 1983 Journal J. Immunol. Section Abstract Doc Link 6300232 Disease Relevance 0 Pain Relevance 0.68
At effector:target cell ratios of 11:1 methionine-enkephalin significantly (P less than 0.05) enhanced NK activity at dilutions of 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml, while leucine-enkephalin significantly (P less than 0.05) enhanced NK activity at dilutions of 10(-4), 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml.
Positive_regulation (enhanced) of NK associated with enkephalin
12) Confidence 0.49 Published 1984 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 6713744 Disease Relevance 0 Pain Relevance 0.69
In fact, both doses of tramadol were able to prevent surgery-induced NK activity suppression, while the drug significantly increased NK activity in normal non-operated animals.
Positive_regulation (increased) of NK associated with tramadol
13) Confidence 0.45 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12161016 Disease Relevance 0.30 Pain Relevance 1.14
At effector:target cell ratios of 11:1 methionine-enkephalin significantly (P less than 0.05) enhanced NK activity at dilutions of 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml, while leucine-enkephalin significantly (P less than 0.05) enhanced NK activity at dilutions of 10(-4), 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml.
Positive_regulation (enhanced) of NK associated with enkephalin
14) Confidence 0.45 Published 1984 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 6713744 Disease Relevance 0 Pain Relevance 0.70
It was suggested that the clinical response would be expected in case of increasing of CD16 cells or CD25 cells and augmentation of NK or LAK activity.
Positive_regulation (augmentation) of NK
15) Confidence 0.45 Published 1993 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 8320888 Disease Relevance 0.75 Pain Relevance 0.08
indicating a critical role of DR5 induction in this death process.
Positive_regulation (induction) of DR5 associated with death
16) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.07 Pain Relevance 0.06
ligands to induce DR5 or downregulate c-FLIP [34].
Positive_regulation (induce) of DR5
17) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.72 Pain Relevance 0.18
Given that sulindac sulfide activated caspase-8 and increased membrane death receptor (DR4 and DR5) protein levels, we evaluated its combination with the endogenous death receptor ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Positive_regulation (increased) of DR5 associated with necrosis, cancer, apoptosis and death
18) Confidence 0.34 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227396 Disease Relevance 1.40 Pain Relevance 0.12
Overexpression of DR5 receptor and its ligand (TRAIL) in chondrocyte-like cells suggested activation of programmed cell death, as also demonstrated by TUNEL-positive cells.
Positive_regulation (Overexpression) of DR5 receptor in chondrocyte associated with apoptosis
19) Confidence 0.33 Published 2009 Journal Histol. Histopathol. Section Abstract Doc Link 19130398 Disease Relevance 0.66 Pain Relevance 0.15
Figure 6 shows that although wild-type DREAM causes activation of the DR3- and DR5-containing promoters, DREAM mutants bearing the mutations L47,52V in the first LCD or L155V in the second LCD did not activate basal or ligand-dependent expression of the DR3 and RAR?
Positive_regulation (activation) of DR5-containing
20) Confidence 0.31 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.13 Pain Relevance 0

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