INT206031

Context Info Confidence 0.33 First Reported 2007 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 7 Total Number 13 Disease Relevance 6.85 Pain Relevance 1.48

mitochondrion (Adc)

Anatomy Link Frequency parietal 2 astrocyte 1 Adc (Mus musculus)

Pain Link Frequency Relevance Heat cva 84 99.08 addiction 1 96.00 imagery 431 91.40 ischemia 42 83.72 Demyelination 36 69.60 Central nervous system 14 68.88 Hippocampus 12 46.72 tolerance 1 9.04 positron emission tomography 44 5.00 Versed 18 5.00

Disease Link Frequency Relevance Heat Brain Disease 13 99.92 Carcinoma 4 99.70 Cerebral Infarction 54 99.08 Hydrocephalus 258 98.88 Edema 120 98.48 Leukoencephalopathies 4 97.92 Infarction 38 95.08 Cancer 136 94.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 72 93.12 Renal Cancer 44 91.08

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, this study highlights an important change in CSF ADC markers in HAART-treated patients.

Regulation (change) of ADC

1) Confidence 0.33 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.30 Pain Relevance 0

Similarly, ADC values in the same ROIs showed no statistical differences between group means.

Regulation (values) of ADC

2) Confidence 0.20 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2847985 Disease Relevance 0.55 Pain Relevance 0

In addition, CBF and ADC values did not differ between C57Bl/6 and Sv/129 mice at any time point or region of interest.

Neg (not) Regulation (values) of ADC

3) Confidence 0.20 Published 2010 Journal Exp Transl Stroke Med Section Abstract Doc Link PMC2847985 Disease Relevance 0.65 Pain Relevance 0.24

ADC is affected by the diffusivity of the water molecules and by the microstructure of the tissue.

Regulation (affected) of ADC

4) Confidence 0.10 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.26 Pain Relevance 0.22

In patients 4 and 5, a thin periventricular rim of lowered ADC values was observed in the parietal white matter (Fig. 2b).

Regulation (values) of ADC in parietal

5) Confidence 0.04 Published 2009 Journal Neuroradiology Section Body Doc Link PMC2744817 Disease Relevance 0.27 Pain Relevance 0.11

Interestingly, however, we observed decreased ADC values in a periventricular rim in the parietal region in two patients.

Regulation (values) of ADC in parietal

6) Confidence 0.04 Published 2009 Journal Neuroradiology Section Body Doc Link PMC2744817 Disease Relevance 0.34 Pain Relevance 0.04

No significant linear correlation between periventricular AQP4 expression and ADC value was found (Figure 9).

Regulation (value) of ADC

7) Confidence 0.02 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.45 Pain Relevance 0.04

ADC values were calculated for each of the ROIs and the results are presented in Figure 3.

Regulation (values) of ADC

8) Confidence 0.02 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.08 Pain Relevance 0.07

The changes in AQP4 expression coincided with significantly increased periventricular ADC value after one and two weeks of hydrocephalus, but no direct linear correlation was found.

Regulation (value) of ADC associated with hydrocephalus

9) Confidence 0.02 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.71 Pain Relevance 0.03

At two weeks, increased abundance of AQP4 expressed in astrocyte processes of the periventricular region was found, together with significant elevated ADC values.

Regulation (values) of ADC in astrocyte

10) Confidence 0.02 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.78 Pain Relevance 0.27

We believe that the changes in ADC values observed in this study are indicative of extracellular edema.

Regulation (values) of ADC associated with edema

11) Confidence 0.02 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.91 Pain Relevance 0.14

ADC values show the presence of periventricular interstitial edema at one and two weeks of hydrocephalus.

Regulation (values) of ADC associated with hydrocephalus and edema

12) Confidence 0.02 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.80 Pain Relevance 0.12

In these studies, ADC values of high-grade clear cell carcinomas were lower than those of low-grade clear cell carcinomas [66], whereas ADC values of non-clear cell carcinomas were higher than those of the clear cell subtype [64].

Spec (clear) Regulation (values) of ADC associated with carcinoma

13) Confidence 0.01 Published 2010 Journal Target Oncol Section Body Doc Link PMC2929340 Disease Relevance 0.76 Pain Relevance 0.20

General Comments

This test has worked.