INT206054

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.11
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1, STAT3) plasma membrane (RAC1, STAT3) nucleoplasm (STAT3)
DNA binding (STAT3) enzyme binding (RAC1) GTPase activity (RAC1)
RAC1 (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 54 99.30 Very High Very High Very High
Inflammation 108 50.00 Quite Low
Arthritis 20 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 4 59.52 Quite High
INFLAMMATION 136 50.00 Quite Low
Aging 42 50.00 Quite Low
Cancer 36 38.96 Quite Low
Apoptosis 16 27.76 Quite Low
Leukemia 4 22.40 Low Low
Myeloid Leukemia 4 20.48 Low Low
Atherosclerosis 88 5.00 Very Low Very Low Very Low
Osteoporosis 70 5.00 Very Low Very Low Very Low
Diabetes Mellitus 66 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of nuclear factor-kappaB activation or disruption of IL-6-mediated signaling through the expression of IkappaBalpha S32AS36A and suppressor of cytokine signaling 3, respectively, blocks Rac1-induced STAT3 activation.
Rac1 Positive_regulation (activation) of STAT3 associated with cytokine
1) Confidence 0.07 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.05 Pain Relevance 0.05
Rac1 expression results in the induction of the IL-6 and IL-6 receptor genes and neutralizing antibodies directed against the IL-6 receptor block Rac1-induced STAT3 activation.
Rac1 Positive_regulation (activation) of STAT3
2) Confidence 0.07 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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