INT206056

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PTK2B, IRF6) cytosol (PTK2B, IRF6) nucleus (PTK2B, IRF6)
cell differentiation (PTK2B) DNA binding (IRF6) protein complex assembly (PTK2B)
PTK2B (Homo sapiens)
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 95.88 Very High Very High Very High
Inflammation 54 60.80 Quite High
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disease 20 81.20 Quite High
Cancer 18 79.96 Quite High
Pituitary Cancer 4 78.24 Quite High
Adenoma 1 68.72 Quite High
INFLAMMATION 68 60.80 Quite High
Aging 21 50.00 Quite Low
Prostate Cancer 1 23.40 Low Low
Coronary Artery Disease 4 5.68 Low Low
Atherosclerosis 44 5.00 Very Low Very Low Very Low
Osteoporosis 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both PTK inhibitors also reduced the LPS activation of nuclear factor-kappa B (NF-kappa B), which is a transcription factor involved in the expression of cytokine genes such as IL-6 and TNF-alpha [107].
PTK Negative_regulation (reduced) of Positive_regulation (activation) of LPS associated with cytokine
1) Confidence 0.00 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.66 Pain Relevance 0.10

General Comments

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