INT206074

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.79
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, IL6ST) extracellular region (IL6, IL6ST) aging (IL6)
plasma membrane (IL6ST)
IL6 (Homo sapiens)
IL6ST (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 179 85.76 High High
cytokine 96 84.72 Quite High
Inflammation 203 82.12 Quite High
Arthritis 49 76.24 Quite High
methotrexate 112 71.64 Quite High
depression 3 67.32 Quite High
Inflammatory response 27 60.80 Quite High
Inflammatory mediators 7 55.76 Quite High
metalloproteinase 8 29.00 Quite Low
chemokine 11 21.60 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 182 85.76 High High
INFLAMMATION 248 82.12 Quite High
Disease 133 81.68 Quite High
Arthritis 41 76.24 Quite High
Dementia 24 73.20 Quite High
Atherosclerosis 136 68.20 Quite High
Depression 3 67.32 Quite High
Stress 9 66.76 Quite High
Osteomyelitis 5 65.48 Quite High
Acute Coronary Syndrome 1 64.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of IL-6R complexed with IL-6 results in homodimerization of gp130 and signal transduction through Janusactivated kinase (JAK)/signal transducers and activators of transcription (STAT) pathways (Heinrich et al 2003).
IL-6 Binding (complexed) of gp130
1) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.73 Pain Relevance 0.22
However, in order to transduce a signal, the combination of IL-6/IL-6R must also bind a ubiquitous transmembrane protein, glycoprotein (gp) 130 (CD130).
IL-6 Binding (bind) of CD130
2) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.61 Pain Relevance 0.18
In cells expressing IL-6R on their cell surface, IL-6 binds to mIL-6R, and by associating with the gp130 protein transmits a signal into the cells.
IL-6 Binding (associating) of gp130
3) Confidence 0.13 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857613 Disease Relevance 0.68 Pain Relevance 0.10
Following gp130 dimerization, IL-6 activates multiple signaling pathways (Ras dependent MAP Kinase cascade, STAT1-STAT3 heterodimer pathway, and STAT3 homodimer pathway) [40-42].


IL-6 Binding (dimerization) of gp130
4) Confidence 0.10 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.12 Pain Relevance 0.06
IL-6 and IL-6 receptor form the IL-6/IL-6 receptor complex, which after binding to gp130 transmits its biological signal to the cell.
IL-6 Binding (binding) of gp130
5) Confidence 0.10 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.62 Pain Relevance 0.09
IL-6 forms a complex by binding to IL-6 R on the cell membrane, which then combines with gp130, which also resides on the cell membrane, forming a homodimer and giving rise to intracellular signal transduction.
IL-6 Binding (binding) of gp130
6) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.42 Pain Relevance 0.25
IL-6 and IL-6 receptor form the IL-6/IL-6 receptor complex, which after binding to gp130 transmits its biological signal to the cell.
IL-6 Binding (binding) of gp130
7) Confidence 0.08 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.62 Pain Relevance 0.09

General Comments

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