INT206076

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) aging (IL6) DNA binding (STAT3)
cytoplasm (STAT3) signal transducer activity (STAT3) cell proliferation (STAT3)
IL6 (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 54 57.28 Quite High
metalloproteinase 2 41.76 Quite Low
cytokine 27 14.00 Low Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 2 74.88 Quite High
INFLAMMATION 68 57.28 Quite High
Leukemia 2 56.24 Quite High
Apoptosis 8 53.04 Quite High
Aging 21 50.00 Quite Low
Cancer 18 47.36 Quite Low
Atherosclerosis 44 5.00 Very Low Very Low Very Low
Osteoporosis 35 5.00 Very Low Very Low Very Low
Diabetes Mellitus 33 5.00 Very Low Very Low Very Low
Cardiovascular Disease 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 and IL-6 receptor gene induction occurs as a result of activated STAT proteins and IL-6 mediates the long-term activation of STAT3 through an autocrine loop.


IL-6 Positive_regulation (mediates) of Positive_regulation (activation) of STAT3
1) Confidence 0.19 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

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