INT206082

Context Info Confidence 0.07 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.30 Pain Relevance 0

extracellular space (IL6, CCL2) aging (IL6, CCL2) extracellular region (IL6, CCL2) signal transduction (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)

IL6 (Homo sapiens) CCL2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 54 50.00 cytokine 27 5.00 Arthritis 10 5.00 Inflammatory response 8 5.00 Inflammatory marker 3 5.00 Pain 3 5.00 tolerance 3 5.00 chemokine 3 5.00 alcohol 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Thrombosis 1 81.24 Dyslipidemia / Combined Dyslipidemia 1 79.60 Coagulation Disorder 2 79.40 Atherosclerosis 44 54.96 INFLAMMATION 68 50.00 Aging 21 50.00 Adhesions 7 25.76 Hyperlipoproteinemia Type Ii 5 13.52 Osteoporosis 35 5.00 Diabetes Mellitus 33 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IL-6 also stimulated MCP-1 protein production and DNA synthesis dose dependently. 50 microM of AG490, a specific JAK 2 inhibitor, partially inhibited STAT 3 activation and MCP-1 production, with near complete inhibition of DNA synthesis [91].

IL-6 Positive_regulation (stimulated) of Gene_expression (production) of MCP-1

1) Confidence 0.07 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.22 Pain Relevance 0

General Comments

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