INT206083

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LDLR, STAT3) nucleoplasm (STAT3) transport (LDLR)
small molecule metabolic process (LDLR) DNA binding (STAT3) cytoplasm (STAT3)
LDLR (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 87.68 High High
Inflammation 54 50.00 Quite Low
imagery 1 13.00 Low Low
antagonist 1 12.64 Low Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 44 88.80 High High
Necrosis 5 76.76 Quite High
Diabetes Mellitus 33 66.60 Quite High
INFLAMMATION 68 50.00 Quite Low
Aging 21 50.00 Quite Low
Osteoporosis 35 48.36 Quite Low
Disease 19 21.84 Low Low
Cardiovascular Disease 20 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
Hypercalcemia 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In one study, Genistein, a nonspecific Tyr-kinase inhibitor, and AG490, a specific inhibitor of JAKs, markedly prevented the CuLDL-induced enhancement of STAT1 and STAT3 Tyr-phosphorylation and DNA-binding activity, suggesting that JAKs are the main kinases involved in STATs' activation by oxidized LDL [125].
CuLDL Positive_regulation (enhancement) of STAT3 Binding (binding) of
1) Confidence 0.02 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

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