INT206087

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1, STAT3) plasma membrane (RAC1, STAT3) nucleoplasm (STAT3)
DNA binding (STAT3) enzyme binding (RAC1) GTPase activity (RAC1)
RAC1 (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 99.30 Very High Very High Very High
Inflammation 54 50.00 Quite Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 2 50.40 Quite High
INFLAMMATION 68 50.00 Quite Low
Aging 21 50.00 Quite Low
Cancer 18 38.96 Quite Low
Apoptosis 8 27.76 Quite Low
Leukemia 2 22.40 Low Low
Myeloid Leukemia 2 20.48 Low Low
Atherosclerosis 44 5.00 Very Low Very Low Very Low
Osteoporosis 35 5.00 Very Low Very Low Very Low
Diabetes Mellitus 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of nuclear factor-kappaB activation or disruption of IL-6-mediated signaling through the expression of IkappaBalpha S32AS36A and suppressor of cytokine signaling 3, respectively, blocks Rac1-induced STAT3 activation.
Rac1 Positive_regulation (induced) of Gene_expression (activation) of STAT3 associated with cytokine
1) Confidence 0.08 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.05 Pain Relevance 0.05

General Comments

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